Angiotensin receptor blockers in patients with hypertrophic cardiomyopathy: A comparison of VANISH and INHERIT randomized trials

Tino Severinsen*, Jens Jakob Thune, Helga Lillian Gudmundsdottir, Christoffer Rasmus Vissing, Kasper Iversen, Carolyn Yung Ho, Henning Bundgaard, Anna Axelsson Raja

*Corresponding author for this work

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Abstract

Purpose: To identify the cause of discrepancy between the INHERIT trial and VANISH trial in regards to disease modification of angiotensin receptor II blockers in hypertrophic cardiomyopathy (HCM). Methods: We replicated the data analysis used in VANISH, converting individual change in each component of the composite endpoint into a z-score and applying this z-score to the INHERIT results. Results: No significant improvement was identified in the composite z-score between the 2 groups at 12-month follow-up (P = .4). With the exception of tissue Doppler systolic (s’) velocity, we found no significant benefit or harm from losartan compared to placebo for any of the individual components of the composite score at 12-month follow-up. Results were similar in analyses without imputed data or when restricted to patients with sarcomeric HCM. Conclusion: Despite applying the potentially more sensitive composite z-score endpoint as in the VANISH trial, no statistically significant benefits from the use of losartan compared to placebo could be detected at 12-month follow-up in patients with overt HCM participating in the INHERIT trial.

Original languageEnglish
JournalAmerican Heart Journal
Volume266
Pages (from-to)198-200
Number of pages3
ISSN0002-8703
DOIs
Publication statusPublished - 2023

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