Anorexia and fat aversion induced by vertical sleeve gastrectomy is attenuated in neurotensin receptor 1–Deficient mice

Cecilia Ratner*, Jae Hoon Shin, Chinmay Dwibedi, Valentina Tremaroli, Anette Bjerregaard, Bolette Hartmann, Fredrik Bäckhed, Gina Leinninger, Randy J. Seeley, Birgitte Holst

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

5 Citations (Scopus)

Abstract

Neurotensin (NT) is an anorexic gut hormone and neuropeptide that increases in circulation following bariatric surgery in humans and rodents. We sought to determine the contribution of NT to the metabolic efficacy of vertical sleeve gastrectomy (VSG). To explore a potential mechanistic role of NT in VSG, we performed sham or VSG surgeries in diet-induced obese NT receptor 1 (NTSR1) wild-type and knockout (ko) mice and compared their weight and fat mass loss, glucose tolerance, food intake, and food preference after surgery. NTSR1 ko mice had reduced initial anorexia and body fat loss. Additionally, NTSR1 ko mice had an attenuated reduction in fat preference following VSG. Results from this study suggest that NTSR1 signaling contributes to the potent effect of VSG to initially reduce food intake following VSG surgeries and potentially also on the effects on macronutrient selection induced by VSG. However, maintenance of long-term weight loss after VSG requires signals in addition to NT.

Original languageEnglish
Article numberbqab130
JournalEndocrinology
Volume162
Issue number9
Number of pages12
ISSN0013-7227
DOIs
Publication statusPublished - 2021

Bibliographical note

Publisher Copyright:
© The Author(s) 2021.

Keywords

  • Fat preference
  • Food intake
  • Neurotensin
  • Vertical sleeve gastrectomy

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