Anti-SARS-CoV-2 vaccination in people with multiple sclerosis: Lessons learnt a year in

Maura Pugliatti; Hans Peter Hartung; Celia Oreja-Guevara; Carlo Pozzilli; Laura Airas; Mona Alkhawajah; Nikolaos Grigoriadis; Melinda Magyari; Bart Van Wijmeersch; Magd Zakaria; Ralf Linker; Andrew Chan; Patrick Vermersch; Thomas Berger

doi:10.3389/fimmu.2022.1045101

Anti-SARS-CoV-2 vaccination in people with multiple sclerosis: Lessons learnt a year in

Maura Pugliatti, Hans Peter Hartung^*, Celia Oreja-Guevara, Carlo Pozzilli, Laura Airas, Mona Alkhawajah, Nikolaos Grigoriadis, Melinda Magyari, Bart Van Wijmeersch, Magd Zakaria, Ralf Linker, Andrew Chan, Patrick Vermersch, Thomas Berger

^*Corresponding author for this work

Research output: Contribution to journal › Review › peer-review

9 Citations (Scopus)

13 Downloads (Pure)

Abstract

It has been over a year since people with multiple sclerosis (pwMS) have been receiving vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). With a negligible number of cases in which vaccination led to a relapse or new onset MS, experts around the world agree that the potential consequences of COVID-19 in pwMS by far outweigh the risks of vaccination. This article reviews the currently available types of anti-SARS-CoV-2 vaccines and the immune responses they elicit in pwMS treated with different DMTs. Findings to date highlight the importance of vaccine timing in relation to DMT dosing to maximize protection, and of encouraging pwMS to get booster doses when offered.

Original language	English
Article number	1045101
Journal	Frontiers in Immunology
Volume	13
Number of pages	8
ISSN	1664-3224
DOIs	https://doi.org/10.3389/fimmu.2022.1045101
Publication status	Published - 2022

Bibliographical note

Publisher Copyright:
Copyright © 2022 Pugliatti, Hartung, Oreja-Guevara, Pozzilli, Airas, Alkhawajah, Grigoriadis, Magyari, Van Wijmeersch, Zakaria, Linker, Chan, Vermersch and Berger.

Keywords

adverse events
COVID-19
disease modifying therapies
immune response
multiple sclerosis
SARS-CoV-2
vaccines

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Pugliatti, M., Hartung, H. P., Oreja-Guevara, C., Pozzilli, C., Airas, L., Alkhawajah, M., Grigoriadis, N., Magyari, M., Van Wijmeersch, B., Zakaria, M., Linker, R., Chan, A., Vermersch, P., & Berger, T. (2022). Anti-SARS-CoV-2 vaccination in people with multiple sclerosis: Lessons learnt a year in. Frontiers in Immunology, 13, Article 1045101. https://doi.org/10.3389/fimmu.2022.1045101

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abstract = "It has been over a year since people with multiple sclerosis (pwMS) have been receiving vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). With a negligible number of cases in which vaccination led to a relapse or new onset MS, experts around the world agree that the potential consequences of COVID-19 in pwMS by far outweigh the risks of vaccination. This article reviews the currently available types of anti-SARS-CoV-2 vaccines and the immune responses they elicit in pwMS treated with different DMTs. Findings to date highlight the importance of vaccine timing in relation to DMT dosing to maximize protection, and of encouraging pwMS to get booster doses when offered.",

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author = "Maura Pugliatti and Hartung, {Hans Peter} and Celia Oreja-Guevara and Carlo Pozzilli and Laura Airas and Mona Alkhawajah and Nikolaos Grigoriadis and Melinda Magyari and {Van Wijmeersch}, Bart and Magd Zakaria and Ralf Linker and Andrew Chan and Patrick Vermersch and Thomas Berger",

note = "Publisher Copyright: Copyright {\textcopyright} 2022 Pugliatti, Hartung, Oreja-Guevara, Pozzilli, Airas, Alkhawajah, Grigoriadis, Magyari, Van Wijmeersch, Zakaria, Linker, Chan, Vermersch and Berger.",

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AU - Pozzilli, Carlo

AU - Airas, Laura

AU - Alkhawajah, Mona

AU - Grigoriadis, Nikolaos

AU - Magyari, Melinda

AU - Van Wijmeersch, Bart

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AB - It has been over a year since people with multiple sclerosis (pwMS) have been receiving vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). With a negligible number of cases in which vaccination led to a relapse or new onset MS, experts around the world agree that the potential consequences of COVID-19 in pwMS by far outweigh the risks of vaccination. This article reviews the currently available types of anti-SARS-CoV-2 vaccines and the immune responses they elicit in pwMS treated with different DMTs. Findings to date highlight the importance of vaccine timing in relation to DMT dosing to maximize protection, and of encouraging pwMS to get booster doses when offered.

KW - adverse events

KW - COVID-19

KW - disease modifying therapies

KW - immune response

KW - multiple sclerosis

KW - SARS-CoV-2

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