ApoB and apoM - New aspects of lipoprotein biology in uremia-induced atherosclerosis

Christina Christoffersen, Emil D. Bartels, Annemarie Aarup Pedersen, Lars Bo Nielsen, Tanja X. Pedersen*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

9 Citations (Scopus)

Abstract

Chronic kidney disease affects as much as 13% of the population, and is associated with a markedly increased risk of developing cardiovascular disease. One of the underlying reasons is accelerated development of atherosclerosis. This can be ascribed both to increased occurrence of traditional cardiovascular risk factors, and to risk factors that may be unique to patients with chronic kidney disease. The latter is reflected in the observation that the current treatment modalities, mainly directed against traditional risk factors, are insufficient to prevent cardiovascular disease in the patient with chronic kidney disease. This review discusses mechanisms accelerating uremic atherosclerosis with a specific focus on the putative roles of apolipoprotein(apo)s B and M that may be particularly important in patients with chronic kidney disease.

Original languageEnglish
JournalEuropean Journal of Pharmacology
Volume816
Pages (from-to)154-160
Number of pages7
ISSN0014-2999
DOIs
Publication statusPublished - Dec 2017

Keywords

  • ApoB
  • ApoM
  • Atherosclerosis
  • Lipoprotein(a)
  • S1P
  • Uremia

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