Abstract
Oxidation of LDL plays a key role in the development of atherosclerosis. HDL may, in part, protect against atherosclerosis by inhibiting LDL oxidation. Overexpression of HDL-associated apolipoprotein M (apoM) protects mice against atherosclerosis through a not yet clarified mechanism. Being a lipocalin, apoM contains a binding pocket for small lipophilic molecules. Here, we report that apoM likely serves as an antioxidant in HDL by binding oxidized phospholipids, thus enhancing the antioxidant potential of HDL.
Original language | English |
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Journal | Atherosclerosis |
Volume | 221 |
Issue number | 1 |
Pages (from-to) | 91-7 |
Number of pages | 7 |
ISSN | 0021-9150 |
DOIs | |
Publication status | Published - 2012 |
Keywords
- Amidines
- Animals
- Antioxidants
- Apolipoproteins
- Atherosclerosis
- Binding Sites
- Cholesterol, Dietary
- Disease Models, Animal
- Humans
- Lipocalins
- Lipoproteins, HDL
- Lipoproteins, LDL
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Mice, Transgenic
- Myristic Acid
- Oxidants
- Oxidation-Reduction
- Phospholipids
- Receptors, LDL
- Recombinant Proteins
- Thiobarbituric Acid Reactive Substances
- Time Factors