Application of a Salt Coformer in a Co-Amorphous Drug System Dramatically Enhances the Glass Transition Temperature: A Case Study of the Ternary System Carbamazepine, Citric Acid, and L-Arginine

Hiroshi Ueda; Wenqi Wu; Korbinian Lobmann; Holger Grohganz; Anette Mullertz; Thomas Rades

doi:10.1021/acs.molpharmaceut.8b00174

Application of a Salt Coformer in a Co-Amorphous Drug System Dramatically Enhances the Glass Transition Temperature: A Case Study of the Ternary System Carbamazepine, Citric Acid, and L-Arginine

Hiroshi Ueda, Wenqi Wu, Korbinian Lobmann, Holger Grohganz, Anette Mullertz, Thomas Rades

Research output: Contribution to journal › Journal article › Research › peer-review

68 Citations (Scopus)

Original language	English
Journal	Molecular Pharmaceutics
Volume	15
Issue number	5
Pages (from-to)	2036-2044
ISSN	1543-8384
DOIs	https://doi.org/10.1021/acs.molpharmaceut.8b00174
Publication status	Published - May 2018

Keywords

co-amorphous
amorphous
glass transition temperature
intermolecular interaction
salt formation
crystallization

Access to Document

10.1021/acs.molpharmaceut.8b00174

Cite this

Application of a Salt Coformer in a Co-Amorphous Drug System Dramatically Enhances the Glass Transition Temperature: A Case Study of the Ternary System Carbamazepine, Citric Acid, and L-Arginine. / Ueda, Hiroshi; Wu, Wenqi; Lobmann, Korbinian ; Grohganz, Holger ; Mullertz, Anette ; Rades, Thomas.

In: Molecular Pharmaceutics, Vol. 15, No. 5, 05.2018, p. 2036-2044.

Research output: Contribution to journal › Journal article › Research › peer-review

Ueda, H, Wu, W, Lobmann, K , Grohganz, H , Mullertz, A & Rades, T 2018, 'Application of a Salt Coformer in a Co-Amorphous Drug System Dramatically Enhances the Glass Transition Temperature: A Case Study of the Ternary System Carbamazepine, Citric Acid, and L-Arginine', Molecular Pharmaceutics, vol. 15, no. 5, pp. 2036-2044. https://doi.org/10.1021/acs.molpharmaceut.8b00174

Ueda, Hiroshi ; Wu, Wenqi ; Lobmann, Korbinian ; Grohganz, Holger ; Mullertz, Anette ; Rades, Thomas. / Application of a Salt Coformer in a Co-Amorphous Drug System Dramatically Enhances the Glass Transition Temperature: A Case Study of the Ternary System Carbamazepine, Citric Acid, and L-Arginine. In: Molecular Pharmaceutics. 2018 ; Vol. 15, No. 5. pp. 2036-2044.

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