Application of interpretable artificial neural networks to early monoclonal antibodies development

Lorenzo Gentiluomo; Dierk Roessner; Dillen Augustijn; Hristo Svilenov; Alina Kulakova; Sujata Mahapatra; Gerhard Winter; Werner Streicher; Åsmund Rinnan; Günther H. J. Peters; Pernille Harris; Wolfgang Friess

doi:10.1016/j.ejpb.2019.05.017

Application of interpretable artificial neural networks to early monoclonal antibodies development

Lorenzo Gentiluomo, Dierk Roessner, Dillen Augustijn, Hristo Svilenov, Alina Kulakova, Sujata Mahapatra, Gerhard Winter, Werner Streicher, Åsmund Rinnan, Günther H. J. Peters, Pernille Harris, Wolfgang Friess

Food Analytics and Biotechnology

Research output: Contribution to journal › Journal article › Research › peer-review

47 Citations (Scopus)

Original language	English
Journal	European Journal of Pharmaceutics and Biopharmaceutics
Volume	141
Pages (from-to)	81-89
ISSN	0939-6411
DOIs	https://doi.org/10.1016/j.ejpb.2019.05.017
Publication status	Published - 2019

Keywords

Neural network(s)
Machine learning
Protein aggregation
Protein formulation
Monoclonal antibody
Stability

Access to Document

10.1016/j.ejpb.2019.05.017

Cite this

Gentiluomo, L., Roessner, D., Augustijn, D., Svilenov, H., Kulakova, A., Mahapatra, S., Winter, G., Streicher, W., Rinnan, Å., Peters, G. H. J., Harris, P., & Friess, W. (2019). Application of interpretable artificial neural networks to early monoclonal antibodies development. European Journal of Pharmaceutics and Biopharmaceutics, 141, 81-89. https://doi.org/10.1016/j.ejpb.2019.05.017

Application of interpretable artificial neural networks to early monoclonal antibodies development. / Gentiluomo, Lorenzo; Roessner, Dierk; Augustijn, Dillen; Svilenov, Hristo; Kulakova, Alina; Mahapatra, Sujata; Winter, Gerhard; Streicher, Werner; Rinnan, Åsmund; Peters, Günther H. J.; Harris, Pernille; Friess, Wolfgang.

In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 141, 2019, p. 81-89.

Research output: Contribution to journal › Journal article › Research › peer-review

Gentiluomo, L, Roessner, D, Augustijn, D, Svilenov, H, Kulakova, A, Mahapatra, S, Winter, G, Streicher, W, Rinnan, Å, Peters, GHJ, Harris, P & Friess, W 2019, 'Application of interpretable artificial neural networks to early monoclonal antibodies development', European Journal of Pharmaceutics and Biopharmaceutics, vol. 141, pp. 81-89. https://doi.org/10.1016/j.ejpb.2019.05.017

Gentiluomo, Lorenzo ; Roessner, Dierk ; Augustijn, Dillen ; Svilenov, Hristo ; Kulakova, Alina ; Mahapatra, Sujata ; Winter, Gerhard ; Streicher, Werner ; Rinnan, Åsmund ; Peters, Günther H. J. ; Harris, Pernille ; Friess, Wolfgang. / Application of interpretable artificial neural networks to early monoclonal antibodies development. In: European Journal of Pharmaceutics and Biopharmaceutics. 2019 ; Vol. 141. pp. 81-89.

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author = "Lorenzo Gentiluomo and Dierk Roessner and Dillen Augustijn and Hristo Svilenov and Alina Kulakova and Sujata Mahapatra and Gerhard Winter and Werner Streicher and {\AA}smund Rinnan and Peters, {G{\"u}nther H. J.} and Pernille Harris and Wolfgang Friess",

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AU - Mahapatra, Sujata

AU - Winter, Gerhard

AU - Streicher, Werner

AU - Rinnan, Åsmund

AU - Peters, Günther H. J.

AU - Harris, Pernille

AU - Friess, Wolfgang

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KW - Stability

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