Association between 8-oxo-7,8-dihydro-2'-deoxyguanosine excretion and risk of postmenopausal breast cancer: nested case-control study

Steffen Loft, Anja Olsen, Peter Møller, Henrik E Poulsen, Anne Tjønneland

Research output: Contribution to journalJournal articleResearchpeer-review

62 Citations (Scopus)

Abstract

Oxidative stress may be important in carcinogenesis and a possible risk factor for breast cancer. The urinary excretion of oxidatively generated biomolecules, such as 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG), represents biomarkers of oxidative stress, reflecting the rate of global damage to DNA in steady state.
Original languageEnglish
JournalCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Volume22
Issue number7
Pages (from-to)1289-96
Number of pages8
ISSN1055-9965
DOIs
Publication statusPublished - Jul 2013

Keywords

  • Breast Neoplasms
  • Case-Control Studies
  • Cohort Studies
  • DNA Damage
  • Denmark
  • Deoxyguanosine
  • Diet
  • Female
  • Follow-Up Studies
  • Humans
  • Middle Aged
  • Oxidative Stress
  • Postmenopause
  • Prospective Studies
  • Receptors, Estrogen
  • Risk Factors
  • Tumor Markers, Biological

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