Association Between hsTnT and NT-proBNP and Peripheral Artery Disease in People with HIV: A Multicentre Danish Cohort Study

Thomas R. Holtveg, Anne Marie Reimer Jensen, Ask Bock, Moises Alberto Suarez-Zdunek, Andreas D. Knudsen, Børge G. Nordestgaard, Shoaib Afzal, Thomas Benfield, Sisse R. Ostrowski, Tor Biering-Sørensen, Ruth Frikke-Schmidt, Susanne D. Nielsen*

*Corresponding author for this work

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Abstract

People with HIV (PWH) have a high risk of peripheral artery disease (PAD), and high-sensitivity troponin (hsTnT) and NT-pro B-type natriuretic peptide (NT-proBNP) may be useful biomarkers for PAD in PWH. We assessed associations between hsTnT and NT-proBNP and both prevalent PAD and de novo PAD. Adult PWH were examined at baseline and after 2 years. Inclusion criteria were (1) measurements of hsTnT and NT-proBNP at baseline and (2) ankle brachial index (ABI) at baseline for prevalent PAD and both visits for de novo PAD. PAD was defined as ABI ≤ 0.9. We included 1011 PWH, and 88 (8.7%) had PAD at baseline. Among 802 PWH, 29 (3.6%) had de novo PAD at follow-up. A doubling in hsTnT concentration was associated with prevalent PAD with an OR 1.41 (95% CI: 1.02–1.96, p = 0.04) and 1.40 (95% CI: 0.99–1.98, p = 0.055) in a base model and an adjusted model, respectively. High hsTnT was associated with a risk ratio of 3.39 (95% CI: 1.24–9.27, p = 0.02) for de novo PAD in an unadjusted model and 3.44 (95% CI: 0.98–12.10, p = 0.05) after adjustments. NT-proBNP was not associated with PAD. Thus, hsTnT was associated with higher odds of prevalent PAD and increased risk of de novo PAD.

Original languageEnglish
Article number401
JournalBiomolecules
Volume15
Issue number3
Number of pages14
ISSN2218-273X
DOIs
Publication statusPublished - 2025

Bibliographical note

Publisher Copyright:
© 2025 by the authors.

Keywords

  • biomarker
  • high-sensitivity troponin T
  • HIV
  • NT-pro B-type natriuretic peptide
  • peripheral arterial disease

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