TY - JOUR
T1 - Association between Urinary Excretion of Cortisol and Markers of Oxidatively Damaged DNA and RNA in Humans
AU - Joergensen, Anders
AU - Broedbaek, Kasper
AU - Weimann, Allan
AU - Semba, Richard D
AU - Ferrucci, Luigi
AU - Joergensen, Martin B
AU - Poulsen, Henrik E
PY - 2011/1/1
Y1 - 2011/1/1
N2 - Chronic psychological stress is associated with accelerated aging, but the underlying biological mechanisms are not known. Prolonged elevations of the stress hormone cortisol is suspected to play a critical role. Through its actions, cortisol may potentially induce oxidatively generated damage to cellular constituents such as DNA and RNA, a phenomenon which has been implicated in aging processes. We investigated the relationship between 24 h excretion of urinary cortisol and markers of oxidatively generated DNA and RNA damage, 8-oxo-7,8-dihydro-2'-deoxyguanosine and 8-oxo-7,8-dihydroguanosine, in a sample of 220 elderly men and women (age 65 - 83 years). We found a robust association between the excretion of cortisol and the oxidation markers (R(2)¿=¿0.15, P
AB - Chronic psychological stress is associated with accelerated aging, but the underlying biological mechanisms are not known. Prolonged elevations of the stress hormone cortisol is suspected to play a critical role. Through its actions, cortisol may potentially induce oxidatively generated damage to cellular constituents such as DNA and RNA, a phenomenon which has been implicated in aging processes. We investigated the relationship between 24 h excretion of urinary cortisol and markers of oxidatively generated DNA and RNA damage, 8-oxo-7,8-dihydro-2'-deoxyguanosine and 8-oxo-7,8-dihydroguanosine, in a sample of 220 elderly men and women (age 65 - 83 years). We found a robust association between the excretion of cortisol and the oxidation markers (R(2)¿=¿0.15, P
U2 - 10.1371/journal.pone.0020795
DO - 10.1371/journal.pone.0020795
M3 - Journal article
C2 - 21687734
SN - 1932-6203
VL - 6
SP - e20795
JO - P L o S One
JF - P L o S One
IS - 6
ER -