Association of Immunoglobulin G3 Hinge Region Length Polymorphism With Cerebral Malaria in Ghanaian Children

Eric Kyei-Baafour; Kwadwo A. Kusi; Fareed K.N. Arthur; Tracy Sarkodie-Addo; Michael Theisen; Daniel Dodoo; Bright Adu

doi:10.1093/infdis/jiab548

Association of Immunoglobulin G3 Hinge Region Length Polymorphism With Cerebral Malaria in Ghanaian Children

Eric Kyei-Baafour, Kwadwo A. Kusi, Fareed K.N. Arthur, Tracy Sarkodie-Addo, Michael Theisen, Daniel Dodoo, Bright Adu

Research output: Contribution to journal › Journal article › Research › peer-review

1 Citation (Scopus)

Abstract

Cerebral malaria (CM) may cause death or long-term neurological damage in children, and several host genetic risk factors have been reported. Malaria-specific immunoglobulin (Ig) G3 antibodies are crucial to human immune response against malaria. The hinge region of IgG3 exhibits length polymorphism (with long [L], medium [M], and short [S] alleles), which may influence its functionality. We studied IgG3 hinge region length polymorphisms in 136 Ghanaian children with malaria. Using logistic regression models, we found that children with the recessive MM allotype encoding medium IgG3 hinge region length had an increased risk of CM (adjusted odds ratio, 6.67 [95% confidence interval,1.30-34.32]; P=.004) . This has implications for future epidemiological studies on CM.

Original language	English
Journal	The Journal of Infectious Diseases
Volume	225
Issue number	10
Pages (from-to)	1786-1790
Number of pages	5
ISSN	0022-1899
DOIs	https://doi.org/10.1093/infdis/jiab548
Publication status	Published - 2022

Bibliographical note

Publisher Copyright:
© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: [email protected].

Keywords

IGHG3 gene
cerebral malaria
IgG3 hinge region
Plasmodium falciparum
polymorphism

Access to Document

10.1093/infdis/jiab548

Cite this

@article{bb0f0506f73e44f1bc561ea83e8d5ac1,

title = "Association of Immunoglobulin G3 Hinge Region Length Polymorphism With Cerebral Malaria in Ghanaian Children",

abstract = "Cerebral malaria (CM) may cause death or long-term neurological damage in children, and several host genetic risk factors have been reported. Malaria-specific immunoglobulin (Ig) G3 antibodies are crucial to human immune response against malaria. The hinge region of IgG3 exhibits length polymorphism (with long [L], medium [M], and short [S] alleles), which may influence its functionality. We studied IgG3 hinge region length polymorphisms in 136 Ghanaian children with malaria. Using logistic regression models, we found that children with the recessive MM allotype encoding medium IgG3 hinge region length had an increased risk of CM (adjusted odds ratio, 6.67 [95% confidence interval,1.30-34.32]; P=.004) . This has implications for future epidemiological studies on CM.",

keywords = "IGHG3 gene, cerebral malaria, IgG3 hinge region, Plasmodium falciparum, polymorphism",

author = "Eric Kyei-Baafour and Kusi, {Kwadwo A.} and Arthur, {Fareed K.N.} and Tracy Sarkodie-Addo and Michael Theisen and Daniel Dodoo and Bright Adu",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: [email protected].",

year = "2022",

doi = "10.1093/infdis/jiab548",

language = "English",

volume = "225",

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T1 - Association of Immunoglobulin G3 Hinge Region Length Polymorphism With Cerebral Malaria in Ghanaian Children

AU - Kyei-Baafour, Eric

AU - Kusi, Kwadwo A.

AU - Arthur, Fareed K.N.

AU - Sarkodie-Addo, Tracy

AU - Theisen, Michael

AU - Dodoo, Daniel

AU - Adu, Bright

PY - 2022

Y1 - 2022

N2 - Cerebral malaria (CM) may cause death or long-term neurological damage in children, and several host genetic risk factors have been reported. Malaria-specific immunoglobulin (Ig) G3 antibodies are crucial to human immune response against malaria. The hinge region of IgG3 exhibits length polymorphism (with long [L], medium [M], and short [S] alleles), which may influence its functionality. We studied IgG3 hinge region length polymorphisms in 136 Ghanaian children with malaria. Using logistic regression models, we found that children with the recessive MM allotype encoding medium IgG3 hinge region length had an increased risk of CM (adjusted odds ratio, 6.67 [95% confidence interval,1.30-34.32]; P=.004) . This has implications for future epidemiological studies on CM.

AB - Cerebral malaria (CM) may cause death or long-term neurological damage in children, and several host genetic risk factors have been reported. Malaria-specific immunoglobulin (Ig) G3 antibodies are crucial to human immune response against malaria. The hinge region of IgG3 exhibits length polymorphism (with long [L], medium [M], and short [S] alleles), which may influence its functionality. We studied IgG3 hinge region length polymorphisms in 136 Ghanaian children with malaria. Using logistic regression models, we found that children with the recessive MM allotype encoding medium IgG3 hinge region length had an increased risk of CM (adjusted odds ratio, 6.67 [95% confidence interval,1.30-34.32]; P=.004) . This has implications for future epidemiological studies on CM.

KW - IGHG3 gene

KW - cerebral malaria

KW - IgG3 hinge region

KW - Plasmodium falciparum

KW - polymorphism

U2 - 10.1093/infdis/jiab548

DO - 10.1093/infdis/jiab548

M3 - Journal article

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SN - 0022-1899

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