Association of interferon-gamma and interleukin 10 genotypes and serum levels with partial clinical remission in type 1 diabetes

B Z Alizadeh; P Hanifi-Moghaddam; P Eerligh; A R van der Slik; H Kolb; A V Kharagjitsingh; A M Pereira Arias; M Ronkainen; M Knip; R Bonfanti; E Bonifacio; Devendra Prasad; T Wilkin; M J Giphart; B P C Koeleman; R Nolsøe; Thomas Mandrup-Poulsen; N C Schloot; B O Roep; DIABMARKER Study Group

doi:10.1111/j.1365-2249.2006.03172.x

Association of interferon-gamma and interleukin 10 genotypes and serum levels with partial clinical remission in type 1 diabetes

B Z Alizadeh, P Hanifi-Moghaddam, P Eerligh, A R van der Slik, H Kolb, A V Kharagjitsingh, A M Pereira Arias, M Ronkainen, M Knip, R Bonfanti, E Bonifacio, Devendra Prasad, T Wilkin, M J Giphart, B P C Koeleman, R Nolsøe, Thomas Mandrup-Poulsen, N C Schloot, B O Roep, DIABMARKER Study Group

Endocrinology and Metabolism

Research output: Contribution to journal › Journal article › Research › peer-review

32 Citations (Scopus)

Abstract

We studied whether serum interferon (IFN)-gamma or interleukin (IL)-10 levels and their corresponding functional polymorphic genotypes are associated with partial remission of type 1 diabetes (T1D). A multi-centre study was undertaken in patients with newly diagnosed T1D and matched controls. T1D patients were followed for 3 months and characterized for remission status. Partial clinical remission was defined as a daily insulin dose

Original language	English
Journal	Clinical and Experimental Immunology
Volume	145
Issue number	3
Pages (from-to)	480-4
Number of pages	5
ISSN	0009-9104
DOIs	https://doi.org/10.1111/j.1365-2249.2006.03172.x
Publication status	Published - 1 Sept 2006

Keywords

Analysis of Variance
Biological Markers
Case-Control Studies
Chi-Square Distribution
Diabetes Mellitus, Type 1
Genetic Predisposition to Disease
Genotype
Humans
Interferon-gamma
Interleukin-10
Remission, Spontaneous
Sample Size

Access to Document

10.1111/j.1365-2249.2006.03172.x

Cite this

Alizadeh, B. Z., Hanifi-Moghaddam, P., Eerligh, P., van der Slik, A. R., Kolb, H., Kharagjitsingh, A. V., Pereira Arias, A. M., Ronkainen, M., Knip, M., Bonfanti, R., Bonifacio, E., Prasad, D., Wilkin, T., Giphart, M. J., Koeleman, B. P. C., Nolsøe, R., Mandrup-Poulsen, T., Schloot, N. C., Roep, B. O., & DIABMARKER Study Group (2006). Association of interferon-gamma and interleukin 10 genotypes and serum levels with partial clinical remission in type 1 diabetes. Clinical and Experimental Immunology, 145(3), 480-4. https://doi.org/10.1111/j.1365-2249.2006.03172.x

Alizadeh, BZ, Hanifi-Moghaddam, P, Eerligh, P, van der Slik, AR, Kolb, H, Kharagjitsingh, AV, Pereira Arias, AM, Ronkainen, M, Knip, M, Bonfanti, R, Bonifacio, E, Prasad, D, Wilkin, T, Giphart, MJ, Koeleman, BPC, Nolsøe, R, Mandrup-Poulsen, T, Schloot, NC, Roep, BO & DIABMARKER Study Group 2006, 'Association of interferon-gamma and interleukin 10 genotypes and serum levels with partial clinical remission in type 1 diabetes', Clinical and Experimental Immunology, vol. 145, no. 3, pp. 480-4. https://doi.org/10.1111/j.1365-2249.2006.03172.x

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abstract = "We studied whether serum interferon (IFN)-gamma or interleukin (IL)-10 levels and their corresponding functional polymorphic genotypes are associated with partial remission of type 1 diabetes (T1D). A multi-centre study was undertaken in patients with newly diagnosed T1D and matched controls. T1D patients were followed for 3 months and characterized for remission status. Partial clinical remission was defined as a daily insulin dose ",

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AU - Alizadeh, B Z

AU - Hanifi-Moghaddam, P

AU - Eerligh, P

AU - van der Slik, A R

AU - Kolb, H

AU - Kharagjitsingh, A V

AU - Pereira Arias, A M

AU - Ronkainen, M

AU - Knip, M

AU - Bonfanti, R

AU - Bonifacio, E

AU - Prasad, Devendra

AU - Wilkin, T

AU - Giphart, M J

AU - Koeleman, B P C

AU - Nolsøe, R

AU - Mandrup-Poulsen, Thomas

AU - Schloot, N C

AU - Roep, B O

AU - DIABMARKER Study Group

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Y1 - 2006/9/1

N2 - We studied whether serum interferon (IFN)-gamma or interleukin (IL)-10 levels and their corresponding functional polymorphic genotypes are associated with partial remission of type 1 diabetes (T1D). A multi-centre study was undertaken in patients with newly diagnosed T1D and matched controls. T1D patients were followed for 3 months and characterized for remission status. Partial clinical remission was defined as a daily insulin dose

AB - We studied whether serum interferon (IFN)-gamma or interleukin (IL)-10 levels and their corresponding functional polymorphic genotypes are associated with partial remission of type 1 diabetes (T1D). A multi-centre study was undertaken in patients with newly diagnosed T1D and matched controls. T1D patients were followed for 3 months and characterized for remission status. Partial clinical remission was defined as a daily insulin dose

KW - Analysis of Variance

KW - Biological Markers

KW - Case-Control Studies

KW - Chi-Square Distribution

KW - Diabetes Mellitus, Type 1

KW - Genetic Predisposition to Disease

KW - Genotype

KW - Humans

KW - Interferon-gamma

KW - Interleukin-10

KW - Remission, Spontaneous

KW - Sample Size

U2 - 10.1111/j.1365-2249.2006.03172.x

DO - 10.1111/j.1365-2249.2006.03172.x

M3 - Journal article

C2 - 16907917

SN - 0009-9104

VL - 145

SP - 480

EP - 484

JO - Clinical and Experimental Immunology

JF - Clinical and Experimental Immunology

IS - 3

ER -