Abstract
Background: Dental caries and enamel defects are the main causes of poor dental health in children, with a substantial impact on their well-being. Use of inhaled asthma medication is a suspected risk factor, but there is a lack of prospective studies investigating this and other prenatal and early life risk factors. Methods: Copenhagen Prospective Studies on Asthma in Childhood 2010 mother–child cohort (COPSAC2010) consists of 700 women who were recruited at 24 weeks of pregnancy. 588 of their children participated in a dental examination at 6 years of age (84%) at the COPSAC2010 research unit. Caries was defined as decayed, missing, or filled surfaces. Enamel defect was defined as demarcated opacity, post-eruptive enamel breakdown, and/or atypical restoration on at least one molar. Caries and enamel defects were assessed in both deciduous and permanent dentitions. Results: We found no associations between inhaled corticosteroids or β2-agonists or asthma symptoms in early childhood and the risk of caries or enamel defects by 6 years of age. Furthermore, we found no strong pre-, peri-, or postnatal risk factors for dental diseases at 6 years, except from nominally significant associations between antibiotic use in pregnancy (OR = 1.25, [1.01–1.54]), maternal education level (OR = 1.57, [1.01–2.45]), having a dog at home (OR = 0.50, [0.27–0.93]), and risk of enamel defects. Conclusions: Use of inhaled corticosteroids, β2-agonists, or asthma symptoms in the first 6 years of life were not associated with the development of caries or enamel defects. This finding is reassuring for parents and physicians prescribing asthma medication for young children.
Original language | English |
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Article number | e14026 |
Journal | Pediatric Allergy and Immunology |
Volume | 34 |
Issue number | 10 |
Number of pages | 11 |
ISSN | 0905-6157 |
DOIs | |
Publication status | Published - 2023 |
Bibliographical note
Publisher Copyright:© 2023 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.
Keywords
- asthma
- asthma medication
- cohort study
- dental caries
- enamel defects
- inhaled corticosteroids
- molar-incisor hypomineralization
- pediatrics
- β2-agonists