TY - JOUR
T1 - AUGMENTATION OF HUMAN LYMPHOCYTE PROLIFERATIVE RESPONSES IN VITROBY PYRIMETHAMINE
AU - BYGBJERG, IB CHRISTIAN
PY - 1981/1/1
Y1 - 1981/1/1
N2 - Thymidine incorporation by human blood mononuclear cells, unstimulated and stimulated with phytohaemagglutinin (PHA), pokeweed mitogen (PWM) and purified protein derivate of tuberculin (PPD) was studied with and without addition of pyrimethamine. Responses were increased significantly by pyrimethamine in the PWM and PPD stimulated cultures, in the PPD cultures even by concentrations of pyrimethamine, which can be achieved with therapeutic doses of this drug. The closely related compound trimethoprim did not alter PHA‐, PWM‐ and PPD‐responses significantly. The possibility of using pyrimethamine ‐ a widely used prophylactic antimalarial ‐ as an immunopotentiator is mentioned. 1981 Acta Pathologica, Microbiologica et Immunologica Scandinavica
AB - Thymidine incorporation by human blood mononuclear cells, unstimulated and stimulated with phytohaemagglutinin (PHA), pokeweed mitogen (PWM) and purified protein derivate of tuberculin (PPD) was studied with and without addition of pyrimethamine. Responses were increased significantly by pyrimethamine in the PWM and PPD stimulated cultures, in the PPD cultures even by concentrations of pyrimethamine, which can be achieved with therapeutic doses of this drug. The closely related compound trimethoprim did not alter PHA‐, PWM‐ and PPD‐responses significantly. The possibility of using pyrimethamine ‐ a widely used prophylactic antimalarial ‐ as an immunopotentiator is mentioned. 1981 Acta Pathologica, Microbiologica et Immunologica Scandinavica
KW - Antimalarials
KW - immunopotention
KW - lymphocyte transformation
KW - pyrimethamine
KW - trimethoprim
UR - http://www.scopus.com/inward/record.url?scp=0019471628&partnerID=8YFLogxK
U2 - 10.1111/j.1699-0463.1981.tb02673.x
DO - 10.1111/j.1699-0463.1981.tb02673.x
M3 - Journal article
C2 - 7293778
AN - SCOPUS:0019471628
VL - 89 C
SP - 111
EP - 114
JO - Acta Pathologica et Microbiologica Scandinavica - Section C Immunology
JF - Acta Pathologica et Microbiologica Scandinavica - Section C Immunology
SN - 0304-1328
IS - 1-6
ER -