TY - JOUR
T1 - Autoimmune psychosis
T2 - an international consensus on an approach to the diagnosis and management of psychosis of suspected autoimmune origin
AU - Pollak, Thomas A.
AU - Lennox, Belinda R.
AU - Müller, Sabine
AU - Benros, Michael E.
AU - Prüss, Harald
AU - Tebartz van Elst, Ludger
AU - Klein, Hans
AU - Steiner, Johann
AU - Frodl, Thomas
AU - Bogerts, Bernhard
AU - Tian, Li
AU - Groc, Laurent
AU - Hasan, Alkomiet
AU - Baune, Bernhard T.
AU - Endres, Dominique
AU - Haroon, Ebrahim
AU - Yolken, Robert
AU - Benedetti, Francesco
AU - Halaris, Angelos
AU - Meyer, Jeffrey H.
AU - Stassen, Hans
AU - Leboyer, Marion
AU - Fuchs, Dietmar
AU - Otto, Markus
AU - Brown, David A.
AU - Vincent, Angela
AU - Najjar, Souhel
AU - Bechter, Karl
PY - 2020
Y1 - 2020
N2 - There is increasing recognition in the neurological and psychiatric literature of patients with so-called isolated psychotic presentations (ie, with no, or minimal, neurological features) who have tested positive for neuronal autoantibodies (principally N-methyl-D-aspartate receptor antibodies) and who have responded to immunotherapies. Although these individuals are sometimes described as having atypical, mild, or attenuated forms of autoimmune encephalitis, some authors feel that that these cases are sufficiently different from typical autoimmune encephalitis to establish a new category of so-called autoimmune psychosis. We briefly review the background, discuss the existing evidence for a form of autoimmune psychosis, and propose a novel, conservative approach to the recognition of possible, probable, and definite autoimmune psychoses for use in psychiatric practice. We also outline the investigations required and the appropriate therapeutic approaches, both psychiatric and immunological, for probable and definite cases of autoimmune psychoses, and discuss the ethical issues posed by this challenging diagnostic category.
AB - There is increasing recognition in the neurological and psychiatric literature of patients with so-called isolated psychotic presentations (ie, with no, or minimal, neurological features) who have tested positive for neuronal autoantibodies (principally N-methyl-D-aspartate receptor antibodies) and who have responded to immunotherapies. Although these individuals are sometimes described as having atypical, mild, or attenuated forms of autoimmune encephalitis, some authors feel that that these cases are sufficiently different from typical autoimmune encephalitis to establish a new category of so-called autoimmune psychosis. We briefly review the background, discuss the existing evidence for a form of autoimmune psychosis, and propose a novel, conservative approach to the recognition of possible, probable, and definite autoimmune psychoses for use in psychiatric practice. We also outline the investigations required and the appropriate therapeutic approaches, both psychiatric and immunological, for probable and definite cases of autoimmune psychoses, and discuss the ethical issues posed by this challenging diagnostic category.
U2 - 10.1016/S2215-0366(19)30290-1
DO - 10.1016/S2215-0366(19)30290-1
M3 - Review
C2 - 31669058
AN - SCOPUS:85076729289
VL - 7
SP - 93
EP - 108
JO - The Lancet Psychiatry
JF - The Lancet Psychiatry
SN - 2215-0366
IS - 1
ER -