Abstract
The purpose of this study was to examine concentration-dependent effects of Azone® (AZ) on the buccal absorption of diazepam (DIAZ). Porcine buccal mucosa was placed in modified Ussing chambers and pretreated with 10 μL of 0%, 5%, 20%, and 50% (w/v) AZ in ethanol. DIAZ was administered to the donor chamber either in solution or a chitosan-based gel. The donor chamber disappearance, receptor chamber appearance, and tissue retention of DIAZ were monitored over 2 h by HPLC, with AZ tissue disposition also measured by liquid chromatography-mass spectrometry profiling of tissue cryosections. DIAZ steady-state flux values significantly (p
Original language | English |
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Article number | 103 |
Journal | Journal of Pharmaceutical Sciences |
Volume | 103 |
Issue number | 4 |
Pages (from-to) | 1133-1141 |
ISSN | 0022-3549 |
DOIs | |
Publication status | Published - 15 Feb 2014 |