Bacterial membrane activity of alpha-peptide/beta-peptoid chimeras: influence of amino acid composition and chain length on the activity against different bacterial strains

Line Hein-Kristensen, Kolja Michael Knapp, Henrik Franzyk, Lone Gram

    Research output: Contribution to journalJournal articleResearchpeer-review

    32 Citations (Scopus)

    Abstract

    Characterization and use of antimicrobial peptides (AMPs) requires that their mode of action is determined. The interaction of membrane-active peptides with their target is often established using model membranes, however, the actual permeabilization of live bacterial cells and subsequent killing is usually not tested. In this report, six a-peptide/ß-peptoid chimeras were examined for the effect of amino acid/peptoid substitutions and chain length on the membrane perturbation and subsequent killing of food-borne and clinical bacterial isolates.
    Original languageEnglish
    JournalB M C Microbiology
    Volume11
    Issue number1
    Pages (from-to)144
    ISSN1471-2180
    DOIs
    Publication statusPublished - 22 Jun 2011

    Keywords

    • Former Faculty of Pharmaceutical Sciences

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