Abstract
Characterization and use of antimicrobial peptides (AMPs) requires that their mode of action is determined. The interaction of membrane-active peptides with their target is often established using model membranes, however, the actual permeabilization of live bacterial cells and subsequent killing is usually not tested. In this report, six a-peptide/ß-peptoid chimeras were examined for the effect of amino acid/peptoid substitutions and chain length on the membrane perturbation and subsequent killing of food-borne and clinical bacterial isolates.
Original language | English |
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Journal | B M C Microbiology |
Volume | 11 |
Issue number | 1 |
Pages (from-to) | 144 |
ISSN | 1471-2180 |
DOIs | |
Publication status | Published - 22 Jun 2011 |
Keywords
- Former Faculty of Pharmaceutical Sciences