Basal insulin and cardiovascular and other outcomes in dysglycemia

Hertzel C Gerstein; Jackie Bosch; Gilles R Dagenais; Rafael Díaz; Hyejung Jung; Aldo P Maggioni; Janice Pogue; Jeffrey Probstfield; Ambady Ramachandran; Matthew C Riddle; Lars E Rydén; Salim Yusuf; ORIGIN Trial Investigators; Thure Krarup; Hans Jørgen Duckert Perrild; Christian Tobias Torp-Pedersen

doi:10.1056/NEJMoa1203858

Basal insulin and cardiovascular and other outcomes in dysglycemia

Hertzel C Gerstein, Jackie Bosch, Gilles R Dagenais, Rafael Díaz, Hyejung Jung, Aldo P Maggioni, Janice Pogue, Jeffrey Probstfield, Ambady Ramachandran, Matthew C Riddle, Lars E Rydén, Salim Yusuf, ORIGIN Trial Investigators, Thure Krarup, Hans Jørgen Duckert Perrild, Christian Tobias Torp-Pedersen

Research output: Contribution to journal › Journal article › Research › peer-review

1406 Citations (Scopus)

Abstract

The provision of sufficient basal insulin to normalize fasting plasma glucose levels may reduce cardiovascular events, but such a possibility has not been formally tested.

Original language	English
Journal	New England Journal of Medicine
Volume	367
Issue number	4
Pages (from-to)	319-28
Number of pages	10
ISSN	0028-4793
DOIs	https://doi.org/10.1056/NEJMoa1203858
Publication status	Published - 2012

Access to Document

10.1056/NEJMoa1203858

Cite this

Gerstein, H. C., Bosch, J., Dagenais, G. R., Díaz, R., Jung, H., Maggioni, A. P., Pogue, J., Probstfield, J., Ramachandran, A., Riddle, M. C., Rydén, L. E., Yusuf, S., ORIGIN Trial Investigators, Krarup, T., Perrild, H. J. D., & Torp-Pedersen, C. T. (2012). Basal insulin and cardiovascular and other outcomes in dysglycemia. New England Journal of Medicine, 367(4), 319-28. https://doi.org/10.1056/NEJMoa1203858

Basal insulin and cardiovascular and other outcomes in dysglycemia. / Gerstein, Hertzel C; Bosch, Jackie; Dagenais, Gilles R; Díaz, Rafael; Jung, Hyejung; Maggioni, Aldo P; Pogue, Janice; Probstfield, Jeffrey; Ramachandran, Ambady; Riddle, Matthew C; Rydén, Lars E; Yusuf, Salim; ORIGIN Trial Investigators; Krarup, Thure; Perrild, Hans Jørgen Duckert ; Torp-Pedersen, Christian Tobias.

In: New England Journal of Medicine, Vol. 367, No. 4, 2012, p. 319-28.

Research output: Contribution to journal › Journal article › Research › peer-review

Gerstein, HC, Bosch, J, Dagenais, GR, Díaz, R, Jung, H, Maggioni, AP, Pogue, J, Probstfield, J, Ramachandran, A, Riddle, MC, Rydén, LE, Yusuf, S, ORIGIN Trial Investigators, Krarup, T, Perrild, HJD & Torp-Pedersen, CT 2012, 'Basal insulin and cardiovascular and other outcomes in dysglycemia', New England Journal of Medicine, vol. 367, no. 4, pp. 319-28. https://doi.org/10.1056/NEJMoa1203858

Gerstein, Hertzel C ; Bosch, Jackie ; Dagenais, Gilles R ; Díaz, Rafael ; Jung, Hyejung ; Maggioni, Aldo P ; Pogue, Janice ; Probstfield, Jeffrey ; Ramachandran, Ambady ; Riddle, Matthew C ; Rydén, Lars E ; Yusuf, Salim ; ORIGIN Trial Investigators ; Krarup, Thure ; Perrild, Hans Jørgen Duckert ; Torp-Pedersen, Christian Tobias. / Basal insulin and cardiovascular and other outcomes in dysglycemia. In: New England Journal of Medicine. 2012 ; Vol. 367, No. 4. pp. 319-28.

@article{46b6ccc5b8ea4ad9a7b8c35718ffa9ad,

title = "Basal insulin and cardiovascular and other outcomes in dysglycemia",

abstract = "The provision of sufficient basal insulin to normalize fasting plasma glucose levels may reduce cardiovascular events, but such a possibility has not been formally tested.",

author = "Gerstein, {Hertzel C} and Jackie Bosch and Dagenais, {Gilles R} and Rafael D{\'i}az and Hyejung Jung and Maggioni, {Aldo P} and Janice Pogue and Jeffrey Probstfield and Ambady Ramachandran and Riddle, {Matthew C} and Ryd{\'e}n, {Lars E} and Salim Yusuf and Torp-Pedersen, {Christian Tobias} and Thure Krarup and Perrild, {Hans J{\o}rgen Duckert} and Torp-Pedersen, {Christian Tobias}",

year = "2012",

doi = "10.1056/NEJMoa1203858",

language = "English",

volume = "367",

pages = "319--28",

journal = "New England Journal of Medicine",

issn = "0028-4793",

publisher = "Massachusetts Medical Society",

number = "4",

}

TY - JOUR

T1 - Basal insulin and cardiovascular and other outcomes in dysglycemia

AU - Gerstein, Hertzel C

AU - Bosch, Jackie

AU - Dagenais, Gilles R

AU - Díaz, Rafael

AU - Jung, Hyejung

AU - Maggioni, Aldo P

AU - Pogue, Janice

AU - Probstfield, Jeffrey

AU - Ramachandran, Ambady

AU - Riddle, Matthew C

AU - Rydén, Lars E

AU - Yusuf, Salim

AU - ORIGIN Trial Investigators

AU - Krarup, Thure

AU - Perrild, Hans Jørgen Duckert

AU - Torp-Pedersen, Christian Tobias

PY - 2012

Y1 - 2012

N2 - The provision of sufficient basal insulin to normalize fasting plasma glucose levels may reduce cardiovascular events, but such a possibility has not been formally tested.

AB - The provision of sufficient basal insulin to normalize fasting plasma glucose levels may reduce cardiovascular events, but such a possibility has not been formally tested.

U2 - 10.1056/NEJMoa1203858

DO - 10.1056/NEJMoa1203858

M3 - Journal article

C2 - 22686416

VL - 367

SP - 319

EP - 328

JO - New England Journal of Medicine

JF - New England Journal of Medicine

SN - 0028-4793

IS - 4

ER -