Beat-to-beat variability of QT intervals is increased in patients with drug-induced long-QT syndrome: a case control pilot study

Martin Hinterseer; Morten Bækgaard Thomsen; Britt-Maria Beckmann; Arne Pfeufer; Rainer Schimpf; H-Erich Wichmann; Gerhard Steinbeck; Marc A Vos; Stefan Kaab

doi:10.1093/eurheartj/ehm586

Beat-to-beat variability of QT intervals is increased in patients with drug-induced long-QT syndrome: a case control pilot study

Martin Hinterseer, Morten Bækgaard Thomsen, Britt-Maria Beckmann, Arne Pfeufer, Rainer Schimpf, H-Erich Wichmann, Gerhard Steinbeck, Marc A Vos, Stefan Kaab

Physiology of circulation, kidney and lung

Research output: Contribution to journal › Journal article › Research › peer-review

97 Citations (Scopus)

Abstract

Torsades de pointes arrhythmias (TdP) occur by definition in the setting of prolonged QT intervals. Animal models of drug induced Long-QT syndrome (dLQTS) have shown higher predictive value for proarrhythmia with beat-to-beat variability of repolarization duration (BVR) when compared with QT intervals. Here, we evaluate variability of QT intervals in patients with a history of drug-induced long QT syndrome (dLQTS) and TdP in absence of a mutation in any of the major LQTS genes.

Original language	English
Journal	European Heart Journal
Volume	29
Issue number	2
Pages (from-to)	185-90
Number of pages	6
ISSN	0195-668X
DOIs	https://doi.org/10.1093/eurheartj/ehm586
Publication status	Published - Jan 2008

Keywords

Aged
Arrhythmias, Cardiac
Case-Control Studies
Disease Susceptibility
Electrocardiography
Female
Heart Rate
Humans
Long QT Syndrome
Male
Middle Aged
Pilot Projects
Predictive Value of Tests
Torsades de Pointes

Access to Document

10.1093/eurheartj/ehm586

Cite this

Beat-to-beat variability of QT intervals is increased in patients with drug-induced long-QT syndrome : a case control pilot study. / Hinterseer, Martin; Thomsen, Morten Bækgaard; Beckmann, Britt-Maria; Pfeufer, Arne; Schimpf, Rainer; Wichmann, H-Erich; Steinbeck, Gerhard; Vos, Marc A; Kaab, Stefan.

In: European Heart Journal, Vol. 29, No. 2, 01.2008, p. 185-90.

Research output: Contribution to journal › Journal article › Research › peer-review

Hinterseer, Martin ; Thomsen, Morten Bækgaard ; Beckmann, Britt-Maria ; Pfeufer, Arne ; Schimpf, Rainer ; Wichmann, H-Erich ; Steinbeck, Gerhard ; Vos, Marc A ; Kaab, Stefan. / Beat-to-beat variability of QT intervals is increased in patients with drug-induced long-QT syndrome : a case control pilot study. In: European Heart Journal. 2008 ; Vol. 29, No. 2. pp. 185-90.

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abstract = "Torsades de pointes arrhythmias (TdP) occur by definition in the setting of prolonged QT intervals. Animal models of drug induced Long-QT syndrome (dLQTS) have shown higher predictive value for proarrhythmia with beat-to-beat variability of repolarization duration (BVR) when compared with QT intervals. Here, we evaluate variability of QT intervals in patients with a history of drug-induced long QT syndrome (dLQTS) and TdP in absence of a mutation in any of the major LQTS genes.",

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