Beat-to-beat variability of QT intervals is increased in patients with drug-induced long-QT syndrome: a case control pilot study

Martin Hinterseer, Morten Bækgaard Thomsen, Britt-Maria Beckmann, Arne Pfeufer, Rainer Schimpf, H-Erich Wichmann, Gerhard Steinbeck, Marc A Vos, Stefan Kaab

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Abstract

Torsades de pointes arrhythmias (TdP) occur by definition in the setting of prolonged QT intervals. Animal models of drug induced Long-QT syndrome (dLQTS) have shown higher predictive value for proarrhythmia with beat-to-beat variability of repolarization duration (BVR) when compared with QT intervals. Here, we evaluate variability of QT intervals in patients with a history of drug-induced long QT syndrome (dLQTS) and TdP in absence of a mutation in any of the major LQTS genes.
Original languageEnglish
JournalEuropean Heart Journal
Volume29
Issue number2
Pages (from-to)185-90
Number of pages6
ISSN0195-668X
DOIs
Publication statusPublished - Jan 2008

Keywords

  • Aged
  • Arrhythmias, Cardiac
  • Case-Control Studies
  • Disease Susceptibility
  • Electrocardiography
  • Female
  • Heart Rate
  • Humans
  • Long QT Syndrome
  • Male
  • Middle Aged
  • Pilot Projects
  • Predictive Value of Tests
  • Torsades de Pointes

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