Beat-to-Beat variability of repolarization determines proarrhythmic outcome in dogs susceptible to drug-induced torsades de pointes

Morten Bækgaard Thomsen, Paul G A Volders, Jet D M Beekman, Jørgen Matz, Marc A Vos

Research output: Contribution to journalJournal articleResearchpeer-review

110 Citations (Scopus)

Abstract

We investigated whether increasing or decreasing beat-to-beat variability of repolarization (BVR) would change drug-induced proarrhythmic outcome accordingly.
Original languageEnglish
JournalJournal of the American College of Cardiology
Volume48
Issue number6
Pages (from-to)1268-76
Number of pages9
DOIs
Publication statusPublished - 19 Sep 2006

Keywords

  • Adenosine Triphosphate
  • Animals
  • Anti-Arrhythmia Agents
  • Arrhythmias, Cardiac
  • Cardiac Pacing, Artificial
  • Cromakalim
  • Disease Susceptibility
  • Dogs
  • Dose-Response Relationship, Drug
  • Heart Rate
  • Imidazoles
  • Indoles
  • Osmolar Concentration
  • Potassium
  • Potassium Channel Blockers
  • Potassium Channels
  • Potassium Chloride
  • Recurrence
  • Torsades de Pointes
  • Ventricular Function

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