Biased Signaling of CCL21 and CCL19 Does Not Rely on N-Terminal Differences, but Markedly on the Chemokine Core Domains and Extracellular Loop 2 of CCR7

Astrid S. Jorgensen; Olav Larsen; Edith Uetz-von Allmen; Michael Lückmann; Daniel F. Legler; Thomas M. Frimurer; Christopher T. Veldkamp; Gertrud M. Hjortø; Mette M. Rosenkilde

doi:10.3389/fimmu.2019.02156

Biased Signaling of CCL21 and CCL19 Does Not Rely on N-Terminal Differences, but Markedly on the Chemokine Core Domains and Extracellular Loop 2 of CCR7

Astrid S. Jorgensen, Olav Larsen, Edith Uetz-von Allmen, Michael Lückmann, Daniel F. Legler, Thomas M. Frimurer, Christopher T. Veldkamp, Gertrud M. Hjortø, Mette M. Rosenkilde

Research output: Contribution to journal › Journal article › Research › peer-review

19 Citations (Scopus)

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Original language	English
Article number	2156
Journal	Frontiers in Immunology
Volume	10
Number of pages	14
ISSN	1664-3224
DOIs	https://doi.org/10.3389/fimmu.2019.02156
Publication status	Published - 2019

Keywords

ligand biased signaling
CCR7
CCL21
CCL19
chemokine core domain
ECL2

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10.3389/fimmu.2019.02156

Biased Signaling of CCL21 and CCL19 Does Not Rely on N-Terminal Differences, but Markedly on the Chemokine Core Domains and Extracellular Loop 2 of CCR7Final published version, 1.59 MB

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Jorgensen, A. S., Larsen, O., Uetz-von Allmen, E., Lückmann, M., Legler, D. F., Frimurer, T. M., Veldkamp, C. T., Hjortø, G. M., & Rosenkilde, M. M. (2019). Biased Signaling of CCL21 and CCL19 Does Not Rely on N-Terminal Differences, but Markedly on the Chemokine Core Domains and Extracellular Loop 2 of CCR7. Frontiers in Immunology, 10, [2156]. https://doi.org/10.3389/fimmu.2019.02156

Biased Signaling of CCL21 and CCL19 Does Not Rely on N-Terminal Differences, but Markedly on the Chemokine Core Domains and Extracellular Loop 2 of CCR7. / Jorgensen, Astrid S.; Larsen, Olav; Uetz-von Allmen, Edith; Lückmann, Michael; Legler, Daniel F.; Frimurer, Thomas M.; Veldkamp, Christopher T.; Hjortø, Gertrud M.; Rosenkilde, Mette M.

In: Frontiers in Immunology, Vol. 10, 2156, 2019.

Research output: Contribution to journal › Journal article › Research › peer-review

Jorgensen, AS , Larsen, O, Uetz-von Allmen, E, Lückmann, M, Legler, DF, Frimurer, TM, Veldkamp, CT, Hjortø, GM & Rosenkilde, MM 2019, 'Biased Signaling of CCL21 and CCL19 Does Not Rely on N-Terminal Differences, but Markedly on the Chemokine Core Domains and Extracellular Loop 2 of CCR7', Frontiers in Immunology, vol. 10, 2156. https://doi.org/10.3389/fimmu.2019.02156

Jorgensen, Astrid S. ; Larsen, Olav ; Uetz-von Allmen, Edith ; Lückmann, Michael ; Legler, Daniel F. ; Frimurer, Thomas M. ; Veldkamp, Christopher T. ; Hjortø, Gertrud M. ; Rosenkilde, Mette M. / Biased Signaling of CCL21 and CCL19 Does Not Rely on N-Terminal Differences, but Markedly on the Chemokine Core Domains and Extracellular Loop 2 of CCR7. In: Frontiers in Immunology. 2019 ; Vol. 10.

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title = "Biased Signaling of CCL21 and CCL19 Does Not Rely on N-Terminal Differences, but Markedly on the Chemokine Core Domains and Extracellular Loop 2 of CCR7",

keywords = "ligand biased signaling, CCR7, CCL21, CCL19, chemokine core domain, ECL2",

author = "Jorgensen, {Astrid S.} and Olav Larsen and {Uetz-von Allmen}, Edith and Michael L{\"u}ckmann and Legler, {Daniel F.} and Frimurer, {Thomas M.} and Veldkamp, {Christopher T.} and Hjort{\o}, {Gertrud M.} and Rosenkilde, {Mette M.}",

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doi = "10.3389/fimmu.2019.02156",

language = "English",

volume = "10",

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TY - JOUR

T1 - Biased Signaling of CCL21 and CCL19 Does Not Rely on N-Terminal Differences, but Markedly on the Chemokine Core Domains and Extracellular Loop 2 of CCR7

AU - Jorgensen, Astrid S.

AU - Larsen, Olav

AU - Uetz-von Allmen, Edith

AU - Lückmann, Michael

AU - Legler, Daniel F.

AU - Frimurer, Thomas M.

AU - Veldkamp, Christopher T.

AU - Hjortø, Gertrud M.

AU - Rosenkilde, Mette M.

PY - 2019

Y1 - 2019

KW - ligand biased signaling

KW - CCR7

KW - CCL21

KW - CCL19

KW - chemokine core domain

KW - ECL2

U2 - 10.3389/fimmu.2019.02156

DO - 10.3389/fimmu.2019.02156

M3 - Journal article

C2 - 31572374

VL - 10

JO - Frontiers in Immunology

JF - Frontiers in Immunology

SN - 1664-3224

M1 - 2156

ER -