Bioanalysis of pharmaceuticals using liquid-phase microextraction combined with liquid chromatography–mass spectrometry

Frederik Hansen; Elisabeth Leere Øiestad; Stig Pedersen-Bjergaard

doi:10.1016/j.jpba.2020.113446

Bioanalysis of pharmaceuticals using liquid-phase microextraction combined with liquid chromatography–mass spectrometry

Frederik Hansen, Elisabeth Leere Øiestad, Stig Pedersen-Bjergaard^*

^*Corresponding author for this work

Microscale Analytical Systems

Research output: Contribution to journal › Review › peer-review

68 Citations (Scopus)

24 Downloads (Pure)

Abstract

In this paper, we review recent research articles on liquid-phase microextraction of drug substances from biological fluids, such as plasma, serum, urine, and saliva. We focus on papers where liquid-phase microextraction is combined with liquid chromatography coupled with mass spectrometry (LC–MS), published in the period 2019−2020. First, we discuss different configurations of liquid-phase microextraction, including dispersive liquid-liquid microextraction (DLLME), dispersive liquid-liquid microextraction based on solidified floating organic droplet (DLLME-SFO), single-drop microextraction (SDME), hollow-fibre liquid-phase microextraction (HF-LPME), solvent bar microextraction (SBME), and electromembrane extraction (EME). Second, we discuss new types of solvents used in liquid-phase microextraction, including ionic liquids, deep eutectic solvents, and nanostructured supramolecular solvents. Especially, we focus on the potential for implementation in routine laboratories, which we consider as the next step for liquid-phase microextraction.

Original language	English
Article number	113446
Journal	Journal of Pharmaceutical and Biomedical Analysis
Volume	189
Number of pages	12
ISSN	0731-7085
DOIs	https://doi.org/10.1016/j.jpba.2020.113446
Publication status	Published - 2020

Keywords

Bioanalysis
Biological fluids
Drug substances
Liquid-phase microextraction
Sample preparation

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10.1016/j.jpba.2020.113446Licence: CC BY

1-s2.0-S0731708520313327-main (1)Final published version, 2.23 MBLicence: CC BY

Cite this

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title = "Bioanalysis of pharmaceuticals using liquid-phase microextraction combined with liquid chromatography–mass spectrometry",

abstract = "In this paper, we review recent research articles on liquid-phase microextraction of drug substances from biological fluids, such as plasma, serum, urine, and saliva. We focus on papers where liquid-phase microextraction is combined with liquid chromatography coupled with mass spectrometry (LC–MS), published in the period 2019−2020. First, we discuss different configurations of liquid-phase microextraction, including dispersive liquid-liquid microextraction (DLLME), dispersive liquid-liquid microextraction based on solidified floating organic droplet (DLLME-SFO), single-drop microextraction (SDME), hollow-fibre liquid-phase microextraction (HF-LPME), solvent bar microextraction (SBME), and electromembrane extraction (EME). Second, we discuss new types of solvents used in liquid-phase microextraction, including ionic liquids, deep eutectic solvents, and nanostructured supramolecular solvents. Especially, we focus on the potential for implementation in routine laboratories, which we consider as the next step for liquid-phase microextraction.",

keywords = "Bioanalysis, Biological fluids, Drug substances, Liquid-phase microextraction, Sample preparation",

author = "Frederik Hansen and {\O}iestad, {Elisabeth Leere} and Stig Pedersen-Bjergaard",

year = "2020",

doi = "10.1016/j.jpba.2020.113446",

language = "English",

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journal = "Journal of Pharmaceutical and Biomedical Analysis",

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T1 - Bioanalysis of pharmaceuticals using liquid-phase microextraction combined with liquid chromatography–mass spectrometry

AU - Hansen, Frederik

AU - Øiestad, Elisabeth Leere

AU - Pedersen-Bjergaard, Stig

PY - 2020

Y1 - 2020

N2 - In this paper, we review recent research articles on liquid-phase microextraction of drug substances from biological fluids, such as plasma, serum, urine, and saliva. We focus on papers where liquid-phase microextraction is combined with liquid chromatography coupled with mass spectrometry (LC–MS), published in the period 2019−2020. First, we discuss different configurations of liquid-phase microextraction, including dispersive liquid-liquid microextraction (DLLME), dispersive liquid-liquid microextraction based on solidified floating organic droplet (DLLME-SFO), single-drop microextraction (SDME), hollow-fibre liquid-phase microextraction (HF-LPME), solvent bar microextraction (SBME), and electromembrane extraction (EME). Second, we discuss new types of solvents used in liquid-phase microextraction, including ionic liquids, deep eutectic solvents, and nanostructured supramolecular solvents. Especially, we focus on the potential for implementation in routine laboratories, which we consider as the next step for liquid-phase microextraction.

AB - In this paper, we review recent research articles on liquid-phase microextraction of drug substances from biological fluids, such as plasma, serum, urine, and saliva. We focus on papers where liquid-phase microextraction is combined with liquid chromatography coupled with mass spectrometry (LC–MS), published in the period 2019−2020. First, we discuss different configurations of liquid-phase microextraction, including dispersive liquid-liquid microextraction (DLLME), dispersive liquid-liquid microextraction based on solidified floating organic droplet (DLLME-SFO), single-drop microextraction (SDME), hollow-fibre liquid-phase microextraction (HF-LPME), solvent bar microextraction (SBME), and electromembrane extraction (EME). Second, we discuss new types of solvents used in liquid-phase microextraction, including ionic liquids, deep eutectic solvents, and nanostructured supramolecular solvents. Especially, we focus on the potential for implementation in routine laboratories, which we consider as the next step for liquid-phase microextraction.

KW - Bioanalysis

KW - Biological fluids

KW - Drug substances

KW - Liquid-phase microextraction

KW - Sample preparation

U2 - 10.1016/j.jpba.2020.113446

DO - 10.1016/j.jpba.2020.113446

M3 - Review

C2 - 32619730

AN - SCOPUS:85087008989

SN - 0731-7085

VL - 189

JO - Journal of Pharmaceutical and Biomedical Analysis

JF - Journal of Pharmaceutical and Biomedical Analysis

M1 - 113446

ER -