TY - JOUR
T1 - Biological and environmental predictors of heterogeneity in neurocognitive ageing
T2 - Evidence from Betula and other longitudinal studies
AU - Nyberg, Lars
AU - Boraxbekk, Carl-Johan
AU - Sörman, Daniel Eriksson
AU - Hansson, Patrik
AU - Herlitz, Agneta
AU - Kauppi, Karolina
AU - Ljungberg, Jessica K.
AU - Lövheim, Hugo
AU - Lundquist, Anders
AU - Adolfsson, Annelie Nordin
AU - Oudin, Anna
AU - Pudas, Sara
AU - Rönnlund, Michael
AU - Stiernstedt, Mikael
AU - Sundström, Anna
AU - Adolfsson, Rolf
N1 - Publisher Copyright:
© 2020 The Author(s)
PY - 2020
Y1 - 2020
N2 - Individual differences in cognitive performance increase with advancing age, reflecting marked cognitive changes in some individuals along with little or no change in others. Genetic and lifestyle factors are assumed to influence cognitive performance in ageing by affecting the magnitude and extent of age-related brain changes (i.e., brain maintenance or atrophy), as well as the ability to recruit compensatory processes. The purpose of this review is to present findings from the Betula study and other longitudinal studies, with a focus on clarifying the role of key biological and environmental factors assumed to underlie individual differences in brain and cognitive ageing. We discuss the vital importance of sampling, analytic methods, consideration of non-ignorable dropout, and related issues for valid conclusions on factors that influence healthy neurocognitive ageing.
AB - Individual differences in cognitive performance increase with advancing age, reflecting marked cognitive changes in some individuals along with little or no change in others. Genetic and lifestyle factors are assumed to influence cognitive performance in ageing by affecting the magnitude and extent of age-related brain changes (i.e., brain maintenance or atrophy), as well as the ability to recruit compensatory processes. The purpose of this review is to present findings from the Betula study and other longitudinal studies, with a focus on clarifying the role of key biological and environmental factors assumed to underlie individual differences in brain and cognitive ageing. We discuss the vital importance of sampling, analytic methods, consideration of non-ignorable dropout, and related issues for valid conclusions on factors that influence healthy neurocognitive ageing.
KW - ageing
KW - brain
KW - brain maintenance, cognitive reserve
KW - genetics
KW - lifestyle
KW - longitudinal
KW - memory
U2 - 10.1016/j.arr.2020.101184
DO - 10.1016/j.arr.2020.101184
M3 - Review
C2 - 32992046
AN - SCOPUS:85092710312
VL - 64
JO - Ageing Research Reviews
JF - Ageing Research Reviews
SN - 1568-1637
M1 - 101184
ER -