Blood pressure, risk of ischemic cerebrovascular and ischemic heart disease, and longevity in alpha(1)-antitrypsin deficiency: the Copenhagen City Heart Study

Morten Dahl, Anne Tybjaerg-Hansen, Henrik Sillesen, Gorm Jensen, Rolf Steffensen, Børge G Nordestgaard

Research output: Contribution to journalJournal articleResearchpeer-review

38 Citations (Scopus)

Abstract

Because elastase in alpha(1)-antitrypsin deficiency may attack elastin in the arterial wall, we tested whether alpha(1)-antitrypsin deficiency is associated with reduced blood pressure, risk of ischemic cerebrovascular (ICVD) and ischemic heart disease (IHD), and longevity.
Original languageEnglish
JournalCirculation
Volume107
Issue number5
Pages (from-to)747-52
Number of pages6
ISSN0009-7322
Publication statusPublished - 11 Feb 2003

Keywords

  • Adult
  • Age Distribution
  • Aged
  • Aged, 80 and over
  • Blood Pressure
  • Brain Ischemia
  • Comorbidity
  • Denmark
  • Female
  • Gene Frequency
  • Genetic Testing
  • Genotype
  • Homozygote
  • Humans
  • Logistic Models
  • Male
  • Middle Aged
  • Myocardial Ischemia
  • Odds Ratio
  • Polymorphism, Genetic
  • Reference Values
  • Risk Assessment
  • alpha 1-Antitrypsin Deficiency

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