TY - JOUR
T1 - Brain capillary pericytes and neurovascular coupling
AU - Grubb, Søren
AU - Lauritzen, Martin
AU - Aalkjær, Christian
N1 - Copyright © 2019. Published by Elsevier Inc.
PY - 2021
Y1 - 2021
N2 - The neurovascular coupling ensures that cerebral activity is matched by the relevant blood flow. The control of the blood flow is mediated by capillaries and by the precapillary aterioles. It is the tone of the mural cells, which include pericytes, smooth muscle cells and cells with intermediate phenotypes between pericytes and smooth muscle cells, that determine the the diameter of the blood vessels and consequently the flow. Here we discuss the structure of these blood vessels and the excitationcontraction coupling of the mural cells.
AB - The neurovascular coupling ensures that cerebral activity is matched by the relevant blood flow. The control of the blood flow is mediated by capillaries and by the precapillary aterioles. It is the tone of the mural cells, which include pericytes, smooth muscle cells and cells with intermediate phenotypes between pericytes and smooth muscle cells, that determine the the diameter of the blood vessels and consequently the flow. Here we discuss the structure of these blood vessels and the excitationcontraction coupling of the mural cells.
U2 - 10.1016/j.cbpa.2020.110893
DO - 10.1016/j.cbpa.2020.110893
M3 - Review
C2 - 33418051
VL - 254
JO - Comparative biochemistry and physiology. Part A, Molecular & integrative physiology
JF - Comparative biochemistry and physiology. Part A, Molecular & integrative physiology
SN - 1095-6433
M1 - 110893
ER -