Brain capillary pericytes and neurovascular coupling

Søren Grubb; Martin Lauritzen; Christian Aalkjær

doi:10.1016/j.cbpa.2020.110893

Brain capillary pericytes and neurovascular coupling

Søren Grubb, Martin Lauritzen, Christian Aalkjær

Research output: Contribution to journal › Review › Research › peer-review

27 Citations (Scopus)

Abstract

The neurovascular coupling ensures that cerebral activity is matched by the relevant blood flow. The control of the blood flow is mediated by capillaries and by the precapillary aterioles. It is the tone of the mural cells, which include pericytes, smooth muscle cells and cells with intermediate phenotypes between pericytes and smooth muscle cells, that determine the the diameter of the blood vessels and consequently the flow. Here we discuss the structure of these blood vessels and the excitationcontraction coupling of the mural cells.

Original language	English
Article number	110893
Journal	Comparative Biochemistry and Physiology - Part A: Molecular & Integrative Physiology
Volume	254
Number of pages	7
ISSN	1095-6433
DOIs	https://doi.org/10.1016/j.cbpa.2020.110893
Publication status	Published - 2021

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10.1016/j.cbpa.2020.110893

Cite this

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title = "Brain capillary pericytes and neurovascular coupling",

abstract = "The neurovascular coupling ensures that cerebral activity is matched by the relevant blood flow. The control of the blood flow is mediated by capillaries and by the precapillary aterioles. It is the tone of the mural cells, which include pericytes, smooth muscle cells and cells with intermediate phenotypes between pericytes and smooth muscle cells, that determine the the diameter of the blood vessels and consequently the flow. Here we discuss the structure of these blood vessels and the excitationcontraction coupling of the mural cells.",

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AU - Grubb, Søren

AU - Lauritzen, Martin

AU - Aalkjær, Christian

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N2 - The neurovascular coupling ensures that cerebral activity is matched by the relevant blood flow. The control of the blood flow is mediated by capillaries and by the precapillary aterioles. It is the tone of the mural cells, which include pericytes, smooth muscle cells and cells with intermediate phenotypes between pericytes and smooth muscle cells, that determine the the diameter of the blood vessels and consequently the flow. Here we discuss the structure of these blood vessels and the excitationcontraction coupling of the mural cells.

AB - The neurovascular coupling ensures that cerebral activity is matched by the relevant blood flow. The control of the blood flow is mediated by capillaries and by the precapillary aterioles. It is the tone of the mural cells, which include pericytes, smooth muscle cells and cells with intermediate phenotypes between pericytes and smooth muscle cells, that determine the the diameter of the blood vessels and consequently the flow. Here we discuss the structure of these blood vessels and the excitationcontraction coupling of the mural cells.

U2 - 10.1016/j.cbpa.2020.110893

DO - 10.1016/j.cbpa.2020.110893

M3 - Review

C2 - 33418051

VL - 254

JO - Comparative biochemistry and physiology. Part A, Molecular & integrative physiology

JF - Comparative biochemistry and physiology. Part A, Molecular & integrative physiology

SN - 1095-6433

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ER -