Brain Connectivity Studies in Schizophrenia: Unravelling the Effects of Antipsychotics

A.B. Nejad; Bjørn Hylsebeck Ebdrup; Birte Yding Glenthøj; Hartwig Roman Siebner

doi:10.2174/157015912803217305

Brain Connectivity Studies in Schizophrenia: Unravelling the Effects of Antipsychotics

A.B. Nejad, Bjørn Hylsebeck Ebdrup, Birte Yding Glenthøj, Hartwig Roman Siebner

Research output: Contribution to journal › Journal article › peer-review

32 Citations (Scopus)

Abstract

Impaired brain connectivity is a hallmark of schizophrenia brain dysfunction. However, the effect of drug treatment and challenges on the dysconnectivity of functional networks in schizophrenia is an understudied area. In this review, we provide an overview of functional magnetic resonance imaging studies examining dysconnectivity in schizophrenia and discuss the few studies which have also attempted to probe connectivity changes with antipsychotic drug treatment. We conclude with a discussion of possible avenues for further investigation.

Original language	English
Journal	Current Neuropharmacology
Volume	10
Issue number	3
Pages (from-to)	219-230
Number of pages	12
ISSN	1570-159X
DOIs	https://doi.org/10.2174/157015912803217305
Publication status	Published - Sep 2012

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10.2174/157015912803217305

Cite this

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title = "Brain Connectivity Studies in Schizophrenia: Unravelling the Effects of Antipsychotics",

abstract = "Impaired brain connectivity is a hallmark of schizophrenia brain dysfunction. However, the effect of drug treatment and challenges on the dysconnectivity of functional networks in schizophrenia is an understudied area. In this review, we provide an overview of functional magnetic resonance imaging studies examining dysconnectivity in schizophrenia and discuss the few studies which have also attempted to probe connectivity changes with antipsychotic drug treatment. We conclude with a discussion of possible avenues for further investigation.",

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AB - Impaired brain connectivity is a hallmark of schizophrenia brain dysfunction. However, the effect of drug treatment and challenges on the dysconnectivity of functional networks in schizophrenia is an understudied area. In this review, we provide an overview of functional magnetic resonance imaging studies examining dysconnectivity in schizophrenia and discuss the few studies which have also attempted to probe connectivity changes with antipsychotic drug treatment. We conclude with a discussion of possible avenues for further investigation.

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