Breast cancer after bilateral risk-reducing mastectomy

A-B Skytte; Dorthe Gylling Crüger; M Gerster; A-V Laenkholm; C Lang; K Brøndum-Nielsen; M K Andersen; Lone E. M. Sunde; Steen Kølvraa; A-M Gerdes

doi:10.1111/j.1399-0004.2010.01604.x

Breast cancer after bilateral risk-reducing mastectomy

A-B Skytte
, Dorthe Gylling Crüger
, M Gerster
, A-V Laenkholm
, C Lang
, K Brøndum-Nielsen
, M K Andersen
, Lone E. M. Sunde
, Steen Kølvraa
, A-M Gerdes

Medical Genetics Program

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

This study aims to evaluate the incidence of breast cancer after risk-reducing mastectomy (RRM) in healthy BRCA mutation carriers. This study is a long-term follow-up of 307 BRCA mutation carriers of whom 96 chose RRM. None of the study participants had a previous history of breast or ovarian cancer nor had they undergone RRM or risk-reducing bilateral salpingo-oophorectomy (BSO) prior to the time of BRCA testing. The annual incidence of post-mastectomy breast cancer was 0.8% compared with 1.7% in the non-operated group. Implications of these findings in relation to genetic counseling and future management are discussed.

Original language	English
Journal	Clinical Genetics
Volume	79
Issue number	5
Pages (from-to)	431-7
Number of pages	7
ISSN	0009-9163
DOIs	https://doi.org/10.1111/j.1399-0004.2010.01604.x
Publication status	Published - 2011

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Cite this

@article{810bc56f9d2c44f59ef3dda69e287562,

title = "Breast cancer after bilateral risk-reducing mastectomy",

abstract = "This study aims to evaluate the incidence of breast cancer after risk-reducing mastectomy (RRM) in healthy BRCA mutation carriers. This study is a long-term follow-up of 307 BRCA mutation carriers of whom 96 chose RRM. None of the study participants had a previous history of breast or ovarian cancer nor had they undergone RRM or risk-reducing bilateral salpingo-oophorectomy (BSO) prior to the time of BRCA testing. The annual incidence of post-mastectomy breast cancer was 0.8\% compared with 1.7\% in the non-operated group. Implications of these findings in relation to genetic counseling and future management are discussed.",

author = "A-B Skytte and Cr{\"u}ger, \{Dorthe Gylling\} and M Gerster and A-V Laenkholm and C Lang and K Br{\o}ndum-Nielsen and Andersen, \{M K\} and Sunde, \{Lone E. M.\} and Steen K{\o}lvraa and A-M Gerdes",

note = "{\textcopyright} 2011 John Wiley \& Sons A/S.",

year = "2011",

doi = "10.1111/j.1399-0004.2010.01604.x",

language = "English",

volume = "79",

pages = "431--7",

journal = "Clinical Genetics",

issn = "0009-9163",

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TY - JOUR

T1 - Breast cancer after bilateral risk-reducing mastectomy

AU - Skytte, A-B

AU - Crüger, Dorthe Gylling

AU - Gerster, M

AU - Laenkholm, A-V

AU - Lang, C

AU - Brøndum-Nielsen, K

AU - Andersen, M K

AU - Sunde, Lone E. M.

AU - Kølvraa, Steen

AU - Gerdes, A-M

PY - 2011

Y1 - 2011

N2 - This study aims to evaluate the incidence of breast cancer after risk-reducing mastectomy (RRM) in healthy BRCA mutation carriers. This study is a long-term follow-up of 307 BRCA mutation carriers of whom 96 chose RRM. None of the study participants had a previous history of breast or ovarian cancer nor had they undergone RRM or risk-reducing bilateral salpingo-oophorectomy (BSO) prior to the time of BRCA testing. The annual incidence of post-mastectomy breast cancer was 0.8% compared with 1.7% in the non-operated group. Implications of these findings in relation to genetic counseling and future management are discussed.

AB - This study aims to evaluate the incidence of breast cancer after risk-reducing mastectomy (RRM) in healthy BRCA mutation carriers. This study is a long-term follow-up of 307 BRCA mutation carriers of whom 96 chose RRM. None of the study participants had a previous history of breast or ovarian cancer nor had they undergone RRM or risk-reducing bilateral salpingo-oophorectomy (BSO) prior to the time of BRCA testing. The annual incidence of post-mastectomy breast cancer was 0.8% compared with 1.7% in the non-operated group. Implications of these findings in relation to genetic counseling and future management are discussed.

U2 - 10.1111/j.1399-0004.2010.01604.x

DO - 10.1111/j.1399-0004.2010.01604.x

M3 - Journal article

C2 - 21199491

SN - 0009-9163

VL - 79

SP - 431

EP - 437

JO - Clinical Genetics

JF - Clinical Genetics

IS - 5

ER -