Breast Cancer Incidence in Relation to Long-Term Low-Level Exposure to Air Pollution in the ELAPSE Pooled Cohort

Ulla Arthur Hvidtfeldt; Jie Chen; Sophia Rodopoulou; Maciej Strak; Kees de Hoogh; Zorana J. Andersen; Tom Bellander; Jørgen Brandt; Daniela Fecht; Francesco Forastiere; John Gulliver; Ole Hertel; Barbara H. Hoffmann; Klea Katsouyanni; Matthias Ketzel; Boel Brynedal; Karin Leander; Petter L.S. Ljungman; Patrik K.E. Magnusson; Gabriele Nagel; Göran Pershagen; Debora Rizzuto; Marie Christine Boutron-Ruault; Evangelia Samoli; Rina So; Massimo Stafoggia; Anne Tjønneland; Roel Vermeulen; W. M.Monique Verschuren; Gudrun Weinmayr; Kathrin Wolf; Jiawei Zhang; Emanuel Zitt; Bert Brunekreef; Gerard Hoek; Ole Raaschou-Nielsen

doi:10.1158/1055-9965.EPI-22-0720

Breast Cancer Incidence in Relation to Long-Term Low-Level Exposure to Air Pollution in the ELAPSE Pooled Cohort

Ulla Arthur Hvidtfeldt, Jie Chen, Sophia Rodopoulou, Maciej Strak, Kees de Hoogh, Zorana J. Andersen, Tom Bellander, Jørgen Brandt, Daniela Fecht, Francesco Forastiere, John Gulliver, Ole Hertel, Barbara H. Hoffmann, Klea Katsouyanni, Matthias Ketzel, Boel Brynedal, Karin Leander, Petter L.S. Ljungman, Patrik K.E. Magnusson, Gabriele NagelGöran Pershagen, Debora Rizzuto, Marie Christine Boutron-Ruault, Evangelia Samoli, Rina So, Massimo Stafoggia, Anne Tjønneland, Roel Vermeulen, W. M.Monique Verschuren, Gudrun Weinmayr, Kathrin Wolf, Jiawei Zhang, Emanuel Zitt, Bert Brunekreef, Gerard Hoek, Ole Raaschou-Nielsen

Section of Environmental Health

Research output: Contribution to journal › Journal article › Research › peer-review

15 Citations (Scopus)

Abstract

BACKGROUND: Established risk factors for breast cancer include genetic disposition, reproductive factors, hormone therapy, and lifestyle-related factors such as alcohol consumption, physical inactivity, smoking, and obesity. More recently a role of environmental exposures, including air pollution, has also been suggested. The aim of this study, was to investigate the relationship between long-term air pollution exposure and breast cancer incidence. METHODS: We conducted a pooled analysis among six European cohorts (n = 199,719) on the association between long-term residential levels of ambient nitrogen dioxide (NO2), fine particles (PM2.5), black carbon (BC), and ozone in the warm season (O3) and breast cancer incidence in women. The selected cohorts represented the lower range of air pollutant concentrations in Europe. We applied Cox proportional hazards models adjusting for potential confounders at the individual and area-level. RESULTS: During 3,592,885 person-years of follow-up, we observed a total of 9,659 incident breast cancer cases. The results of the fully adjusted linear analyses showed a HR (95% confidence interval) of 1.03 (1.00-1.06) per 10 μg/m³ NO2, 1.06 (1.01-1.11) per 5 μg/m³ PM2.5, 1.03 (0.99-1.06) per 0.5 10-5 m-1 BC, and 0.98 (0.94-1.01) per 10 μg/m³ O3. The effect estimates were most pronounced in the group of middle-aged women (50-54 years) and among never smokers. CONCLUSIONS: The results were in support of an association between especially PM2.5 and breast cancer. IMPACT: The findings of this study suggest a role of exposure to NO2, PM2.5, and BC in development of breast cancer.

Original language	English
Journal	Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Volume	32
Issue number	1
Pages (from-to)	105-113
Number of pages	9
ISSN	1055-9965
DOIs	https://doi.org/10.1158/1055-9965.EPI-22-0720
Publication status	Published - 2023

Bibliographical note

Publisher Copyright:
©2022 American Association for Cancer Research.

Access to Document

10.1158/1055-9965.EPI-22-0720

Cite this

Hvidtfeldt, U. A., Chen, J., Rodopoulou, S., Strak, M., de Hoogh, K., Andersen, Z. J., Bellander, T., Brandt, J., Fecht, D., Forastiere, F., Gulliver, J., Hertel, O., Hoffmann, B. H., Katsouyanni, K., Ketzel, M., Brynedal, B., Leander, K., Ljungman, P. L. S., Magnusson, P. K. E., ... Raaschou-Nielsen, O. (2023). Breast Cancer Incidence in Relation to Long-Term Low-Level Exposure to Air Pollution in the ELAPSE Pooled Cohort. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 32(1), 105-113. https://doi.org/10.1158/1055-9965.EPI-22-0720

Breast Cancer Incidence in Relation to Long-Term Low-Level Exposure to Air Pollution in the ELAPSE Pooled Cohort. / Hvidtfeldt, Ulla Arthur; Chen, Jie; Rodopoulou, Sophia; Strak, Maciej; de Hoogh, Kees; Andersen, Zorana J.; Bellander, Tom; Brandt, Jørgen; Fecht, Daniela; Forastiere, Francesco; Gulliver, John; Hertel, Ole; Hoffmann, Barbara H.; Katsouyanni, Klea; Ketzel, Matthias; Brynedal, Boel; Leander, Karin; Ljungman, Petter L.S.; Magnusson, Patrik K.E.; Nagel, Gabriele; Pershagen, Göran; Rizzuto, Debora; Boutron-Ruault, Marie Christine; Samoli, Evangelia; So, Rina; Stafoggia, Massimo; Tjønneland, Anne; Vermeulen, Roel; Verschuren, W. M.Monique; Weinmayr, Gudrun; Wolf, Kathrin; Zhang, Jiawei; Zitt, Emanuel; Brunekreef, Bert; Hoek, Gerard; Raaschou-Nielsen, Ole.

In: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 32, No. 1, 2023, p. 105-113.

Research output: Contribution to journal › Journal article › Research › peer-review

Hvidtfeldt, UA, Chen, J, Rodopoulou, S, Strak, M, de Hoogh, K, Andersen, ZJ, Bellander, T, Brandt, J, Fecht, D, Forastiere, F, Gulliver, J, Hertel, O, Hoffmann, BH, Katsouyanni, K, Ketzel, M, Brynedal, B, Leander, K, Ljungman, PLS, Magnusson, PKE, Nagel, G, Pershagen, G, Rizzuto, D, Boutron-Ruault, MC, Samoli, E, So, R, Stafoggia, M, Tjønneland, A, Vermeulen, R, Verschuren, WMM, Weinmayr, G, Wolf, K, Zhang, J, Zitt, E, Brunekreef, B, Hoek, G & Raaschou-Nielsen, O 2023, 'Breast Cancer Incidence in Relation to Long-Term Low-Level Exposure to Air Pollution in the ELAPSE Pooled Cohort', Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, vol. 32, no. 1, pp. 105-113. https://doi.org/10.1158/1055-9965.EPI-22-0720

Hvidtfeldt UA, Chen J, Rodopoulou S, Strak M, de Hoogh K, Andersen ZJ et al. Breast Cancer Incidence in Relation to Long-Term Low-Level Exposure to Air Pollution in the ELAPSE Pooled Cohort. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2023;32(1):105-113. https://doi.org/10.1158/1055-9965.EPI-22-0720

Hvidtfeldt, Ulla Arthur ; Chen, Jie ; Rodopoulou, Sophia ; Strak, Maciej ; de Hoogh, Kees ; Andersen, Zorana J. ; Bellander, Tom ; Brandt, Jørgen ; Fecht, Daniela ; Forastiere, Francesco ; Gulliver, John ; Hertel, Ole ; Hoffmann, Barbara H. ; Katsouyanni, Klea ; Ketzel, Matthias ; Brynedal, Boel ; Leander, Karin ; Ljungman, Petter L.S. ; Magnusson, Patrik K.E. ; Nagel, Gabriele ; Pershagen, Göran ; Rizzuto, Debora ; Boutron-Ruault, Marie Christine ; Samoli, Evangelia ; So, Rina ; Stafoggia, Massimo ; Tjønneland, Anne ; Vermeulen, Roel ; Verschuren, W. M.Monique ; Weinmayr, Gudrun ; Wolf, Kathrin ; Zhang, Jiawei ; Zitt, Emanuel ; Brunekreef, Bert ; Hoek, Gerard ; Raaschou-Nielsen, Ole. / Breast Cancer Incidence in Relation to Long-Term Low-Level Exposure to Air Pollution in the ELAPSE Pooled Cohort. In: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2023 ; Vol. 32, No. 1. pp. 105-113.

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title = "Breast Cancer Incidence in Relation to Long-Term Low-Level Exposure to Air Pollution in the ELAPSE Pooled Cohort",

abstract = "BACKGROUND: Established risk factors for breast cancer include genetic disposition, reproductive factors, hormone therapy, and lifestyle-related factors such as alcohol consumption, physical inactivity, smoking, and obesity. More recently a role of environmental exposures, including air pollution, has also been suggested. The aim of this study, was to investigate the relationship between long-term air pollution exposure and breast cancer incidence. METHODS: We conducted a pooled analysis among six European cohorts (n = 199,719) on the association between long-term residential levels of ambient nitrogen dioxide (NO2), fine particles (PM2.5), black carbon (BC), and ozone in the warm season (O3) and breast cancer incidence in women. The selected cohorts represented the lower range of air pollutant concentrations in Europe. We applied Cox proportional hazards models adjusting for potential confounders at the individual and area-level. RESULTS: During 3,592,885 person-years of follow-up, we observed a total of 9,659 incident breast cancer cases. The results of the fully adjusted linear analyses showed a HR (95% confidence interval) of 1.03 (1.00-1.06) per 10 μg/m³ NO2, 1.06 (1.01-1.11) per 5 μg/m³ PM2.5, 1.03 (0.99-1.06) per 0.5 10-5 m-1 BC, and 0.98 (0.94-1.01) per 10 μg/m³ O3. The effect estimates were most pronounced in the group of middle-aged women (50-54 years) and among never smokers. CONCLUSIONS: The results were in support of an association between especially PM2.5 and breast cancer. IMPACT: The findings of this study suggest a role of exposure to NO2, PM2.5, and BC in development of breast cancer.",

author = "Hvidtfeldt, {Ulla Arthur} and Jie Chen and Sophia Rodopoulou and Maciej Strak and {de Hoogh}, Kees and Andersen, {Zorana J.} and Tom Bellander and J{\o}rgen Brandt and Daniela Fecht and Francesco Forastiere and John Gulliver and Ole Hertel and Hoffmann, {Barbara H.} and Klea Katsouyanni and Matthias Ketzel and Boel Brynedal and Karin Leander and Ljungman, {Petter L.S.} and Magnusson, {Patrik K.E.} and Gabriele Nagel and G{\"o}ran Pershagen and Debora Rizzuto and Boutron-Ruault, {Marie Christine} and Evangelia Samoli and Rina So and Massimo Stafoggia and Anne Tj{\o}nneland and Roel Vermeulen and Verschuren, {W. M.Monique} and Gudrun Weinmayr and Kathrin Wolf and Jiawei Zhang and Emanuel Zitt and Bert Brunekreef and Gerard Hoek and Ole Raaschou-Nielsen",

note = "Publisher Copyright: {\textcopyright}2022 American Association for Cancer Research.",

year = "2023",

doi = "10.1158/1055-9965.EPI-22-0720",

language = "English",

volume = "32",

pages = "105--113",

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T1 - Breast Cancer Incidence in Relation to Long-Term Low-Level Exposure to Air Pollution in the ELAPSE Pooled Cohort

AU - Hvidtfeldt, Ulla Arthur

AU - Chen, Jie

AU - Rodopoulou, Sophia

AU - Strak, Maciej

AU - de Hoogh, Kees

AU - Andersen, Zorana J.

AU - Bellander, Tom

AU - Brandt, Jørgen

AU - Fecht, Daniela

AU - Forastiere, Francesco

AU - Gulliver, John

AU - Hertel, Ole

AU - Hoffmann, Barbara H.

AU - Katsouyanni, Klea

AU - Ketzel, Matthias

AU - Brynedal, Boel

AU - Leander, Karin

AU - Ljungman, Petter L.S.

AU - Magnusson, Patrik K.E.

AU - Nagel, Gabriele

AU - Pershagen, Göran

AU - Rizzuto, Debora

AU - Boutron-Ruault, Marie Christine

AU - Samoli, Evangelia

AU - So, Rina

AU - Stafoggia, Massimo

AU - Tjønneland, Anne

AU - Vermeulen, Roel

AU - Verschuren, W. M.Monique

AU - Weinmayr, Gudrun

AU - Wolf, Kathrin

AU - Zhang, Jiawei

AU - Zitt, Emanuel

AU - Brunekreef, Bert

AU - Hoek, Gerard

AU - Raaschou-Nielsen, Ole

PY - 2023

Y1 - 2023

N2 - BACKGROUND: Established risk factors for breast cancer include genetic disposition, reproductive factors, hormone therapy, and lifestyle-related factors such as alcohol consumption, physical inactivity, smoking, and obesity. More recently a role of environmental exposures, including air pollution, has also been suggested. The aim of this study, was to investigate the relationship between long-term air pollution exposure and breast cancer incidence. METHODS: We conducted a pooled analysis among six European cohorts (n = 199,719) on the association between long-term residential levels of ambient nitrogen dioxide (NO2), fine particles (PM2.5), black carbon (BC), and ozone in the warm season (O3) and breast cancer incidence in women. The selected cohorts represented the lower range of air pollutant concentrations in Europe. We applied Cox proportional hazards models adjusting for potential confounders at the individual and area-level. RESULTS: During 3,592,885 person-years of follow-up, we observed a total of 9,659 incident breast cancer cases. The results of the fully adjusted linear analyses showed a HR (95% confidence interval) of 1.03 (1.00-1.06) per 10 μg/m³ NO2, 1.06 (1.01-1.11) per 5 μg/m³ PM2.5, 1.03 (0.99-1.06) per 0.5 10-5 m-1 BC, and 0.98 (0.94-1.01) per 10 μg/m³ O3. The effect estimates were most pronounced in the group of middle-aged women (50-54 years) and among never smokers. CONCLUSIONS: The results were in support of an association between especially PM2.5 and breast cancer. IMPACT: The findings of this study suggest a role of exposure to NO2, PM2.5, and BC in development of breast cancer.

AB - BACKGROUND: Established risk factors for breast cancer include genetic disposition, reproductive factors, hormone therapy, and lifestyle-related factors such as alcohol consumption, physical inactivity, smoking, and obesity. More recently a role of environmental exposures, including air pollution, has also been suggested. The aim of this study, was to investigate the relationship between long-term air pollution exposure and breast cancer incidence. METHODS: We conducted a pooled analysis among six European cohorts (n = 199,719) on the association between long-term residential levels of ambient nitrogen dioxide (NO2), fine particles (PM2.5), black carbon (BC), and ozone in the warm season (O3) and breast cancer incidence in women. The selected cohorts represented the lower range of air pollutant concentrations in Europe. We applied Cox proportional hazards models adjusting for potential confounders at the individual and area-level. RESULTS: During 3,592,885 person-years of follow-up, we observed a total of 9,659 incident breast cancer cases. The results of the fully adjusted linear analyses showed a HR (95% confidence interval) of 1.03 (1.00-1.06) per 10 μg/m³ NO2, 1.06 (1.01-1.11) per 5 μg/m³ PM2.5, 1.03 (0.99-1.06) per 0.5 10-5 m-1 BC, and 0.98 (0.94-1.01) per 10 μg/m³ O3. The effect estimates were most pronounced in the group of middle-aged women (50-54 years) and among never smokers. CONCLUSIONS: The results were in support of an association between especially PM2.5 and breast cancer. IMPACT: The findings of this study suggest a role of exposure to NO2, PM2.5, and BC in development of breast cancer.

U2 - 10.1158/1055-9965.EPI-22-0720

DO - 10.1158/1055-9965.EPI-22-0720

M3 - Journal article

C2 - 36215200

AN - SCOPUS:85141487630

VL - 32

SP - 105

EP - 113

JO - Cancer Epidemiology, Biomarkers & Prevention

JF - Cancer Epidemiology, Biomarkers & Prevention

SN - 1055-9965

IS - 1

ER -