Bringing Radiotracing to Titanium-Based Antineoplastics: Solid Phase Radiosynthesis, PET and ex Vivo Evaluation of Antitumor Agent [45Ti](salan)Ti(dipic)

Gregory W. Severin; Carsten H. Nielsen; Andreas I. Jensen; Jesper Fonslet; Andreas Kjær; Fedor Zhuravlev

doi:10.1021/acs.jmedchem.5b01167

Bringing Radiotracing to Titanium-Based Antineoplastics: Solid Phase Radiosynthesis, PET and ex Vivo Evaluation of Antitumor Agent [⁴⁵Ti](salan)Ti(dipic)

Gregory W. Severin, Carsten H. Nielsen, Andreas I. Jensen, Jesper Fonslet, Andreas Kjær, Fedor Zhuravlev

Research output: Contribution to journal › Journal article › Research › peer-review

43 Citations (Scopus)

Abstract

We present a novel solid-phase based ⁴⁵Ti radiolabeling methodology and the implementation of ⁴⁵Ti-PET in titanium-based antineoplastics using the showcase compound [⁴⁵Ti](salan)Ti(dipic). This development is intended to allow elucidation of the biodistribution and pharmacokinetics of promising new Ti-based therapeutics.

Original language	English
Journal	Journal of Medicinal Chemistry
Volume	58
Issue number	18
Pages (from-to)	7591-7595
Number of pages	5
ISSN	0022-2623
DOIs	https://doi.org/10.1021/acs.jmedchem.5b01167
Publication status	Published - 24 Sept 2015

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Bringing Radiotracing to Titanium-Based Antineoplastics: Solid Phase Radiosynthesis, PET and ex Vivo Evaluation of Antitumor Agent [⁴⁵Ti](salan)Ti(dipic). / Severin, Gregory W.; Nielsen, Carsten H.; Jensen, Andreas I. et al.
In: Journal of Medicinal Chemistry, Vol. 58, No. 18, 24.09.2015, p. 7591-7595.

Research output: Contribution to journal › Journal article › Research › peer-review

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