C-Terminal lactamization of peptides

Niklas H. Fischer; Daniel S. Nielsen; Daniel Palmer; Morten Meldal; Frederik Diness

doi:10.1039/D0CC06018F

C-Terminal lactamization of peptides

Niklas H. Fischer, Daniel S. Nielsen, Daniel Palmer, Morten Meldal, Frederik Diness

Research output: Contribution to journal › Journal article › Research › peer-review

5 Citations (Scopus)

Abstract

Solid-phase synthesis of peptides (SPPS) with release through formation of C-terminal γ-, δ-, or ε-lactams is presented. The natural products ciliatamide A and C were synthesized in up to 90% yield. Peptides carrying C-terminal lactams were shown to possess increased bio-stability and comparable biological activity as compared to the parent non-lactamized peptide amides.

Original language	English
Journal	Chemical Communications
Volume	57
Issue number	7
Pages (from-to)	895-898
Number of pages	4
ISSN	1359-7345
DOIs	https://doi.org/10.1039/D0CC06018F
Publication status	Published - 2021

Access to Document

10.1039/D0CC06018F

Cite this

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title = "C-Terminal lactamization of peptides",

abstract = "Solid-phase synthesis of peptides (SPPS) with release through formation of C-terminal γ-, δ-, or ε-lactams is presented. The natural products ciliatamide A and C were synthesized in up to 90% yield. Peptides carrying C-terminal lactams were shown to possess increased bio-stability and comparable biological activity as compared to the parent non-lactamized peptide amides.",

author = "Fischer, {Niklas H.} and Nielsen, {Daniel S.} and Daniel Palmer and Morten Meldal and Frederik Diness",

year = "2021",

doi = "10.1039/D0CC06018F",

language = "English",

volume = "57",

pages = "895--898",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "7",

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TY - JOUR

T1 - C-Terminal lactamization of peptides

AU - Fischer, Niklas H.

AU - Nielsen, Daniel S.

AU - Palmer, Daniel

AU - Meldal, Morten

AU - Diness, Frederik

PY - 2021

Y1 - 2021

N2 - Solid-phase synthesis of peptides (SPPS) with release through formation of C-terminal γ-, δ-, or ε-lactams is presented. The natural products ciliatamide A and C were synthesized in up to 90% yield. Peptides carrying C-terminal lactams were shown to possess increased bio-stability and comparable biological activity as compared to the parent non-lactamized peptide amides.

AB - Solid-phase synthesis of peptides (SPPS) with release through formation of C-terminal γ-, δ-, or ε-lactams is presented. The natural products ciliatamide A and C were synthesized in up to 90% yield. Peptides carrying C-terminal lactams were shown to possess increased bio-stability and comparable biological activity as compared to the parent non-lactamized peptide amides.

U2 - 10.1039/D0CC06018F

DO - 10.1039/D0CC06018F

M3 - Journal article

VL - 57

SP - 895

EP - 898

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

IS - 7

ER -