Cad1 turns ATP into phage poison

Jinzhong Lin; Yuvaraj Bhoobalan-Chitty; Xu Peng

doi:10.1016/j.chom.2024.12.013

Cad1 turns ATP into phage poison

Jinzhong Lin, Yuvaraj Bhoobalan-Chitty, Xu Peng^*

^*Corresponding author for this work

Functional Genomics

Research output: Contribution to journal › Comment/debate › Research › peer-review

Abstract

Type III CRISPR-Cas executes a multifaceted anti-phage response, activating effectors such as a nuclease or membrane depolarizer. In a recent Cell paper, Baca and Majumder et al.¹ report an accessory effector, Cad1, which deaminates ATP into ITP, causing ITP accumulation and host growth arrest, thereby inhibiting phage propagation.

Original language	English
Journal	Cell Host and Microbe
Volume	33
Issue number	1
Pages (from-to)	8-10
Number of pages	3
ISSN	1931-3128
DOIs	https://doi.org/10.1016/j.chom.2024.12.013
Publication status	Published - 2025

Bibliographical note

Publisher Copyright:
© 2024 Elsevier Inc.

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10.1016/j.chom.2024.12.013

Cite this

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title = "Cad1 turns ATP into phage poison",

abstract = "Type III CRISPR-Cas executes a multifaceted anti-phage response, activating effectors such as a nuclease or membrane depolarizer. In a recent Cell paper, Baca and Majumder et al.1 report an accessory effector, Cad1, which deaminates ATP into ITP, causing ITP accumulation and host growth arrest, thereby inhibiting phage propagation.",

author = "Jinzhong Lin and Yuvaraj Bhoobalan-Chitty and Xu Peng",

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language = "English",

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AU - Lin, Jinzhong

AU - Bhoobalan-Chitty, Yuvaraj

AU - Peng, Xu

PY - 2025

Y1 - 2025

N2 - Type III CRISPR-Cas executes a multifaceted anti-phage response, activating effectors such as a nuclease or membrane depolarizer. In a recent Cell paper, Baca and Majumder et al.1 report an accessory effector, Cad1, which deaminates ATP into ITP, causing ITP accumulation and host growth arrest, thereby inhibiting phage propagation.

AB - Type III CRISPR-Cas executes a multifaceted anti-phage response, activating effectors such as a nuclease or membrane depolarizer. In a recent Cell paper, Baca and Majumder et al.1 report an accessory effector, Cad1, which deaminates ATP into ITP, causing ITP accumulation and host growth arrest, thereby inhibiting phage propagation.

U2 - 10.1016/j.chom.2024.12.013

DO - 10.1016/j.chom.2024.12.013

M3 - Comment/debate

C2 - 39788098

AN - SCOPUS:85213840602

VL - 33

SP - 8

EP - 10

JO - Cell Host & Microbe

JF - Cell Host & Microbe

SN - 1931-3128

IS - 1

ER -