Calcitonin gene-related peptide triggers migraine-like attacks in patients with migraine with aura

Jakob Møller Hansen; Anne Werner Hauge; J. Olesen; Messoud Ashina; Jes Olesen

doi:http://dx.doi.org/10.1177/0333102410368444

Calcitonin gene-related peptide triggers migraine-like attacks in patients with migraine with aura

Jakob Møller Hansen, Anne Werner Hauge, J. Olesen, Messoud Ashina, Jes Olesen

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

Calcitonin gene-related peptide (CGRP) is a key molecule in migraine pathogenesis. Intravenous CGRP infusion triggers delayed migraine-like attacks in patients with migraine without aura (MO). In contrast to patients with MO, in prior studies patients with familial hemiplegic migraine (FHM) did not report more migraine-like attacks compared to controls. Whether CGRP triggers migraine in patients with typical (non-hemiplegic) migraine with aura is (MA) unknown. In the present study we examined the migraine inducing effect of CGRP infusion in patients suffering from MA and healthy controls.

Original language	English
Journal	Cephalalgia
Volume	30
Issue number	10
Pages (from-to)	1179-86
Number of pages	8
ISSN	0333-1024
DOIs	https://doi.org/10.1177/0333102410368444
Publication status	Published - 2010

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http://dx.doi.org/10.1177/0333102410368444

Cite this

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title = "Calcitonin gene-related peptide triggers migraine-like attacks in patients with migraine with aura",

abstract = "Calcitonin gene-related peptide (CGRP) is a key molecule in migraine pathogenesis. Intravenous CGRP infusion triggers delayed migraine-like attacks in patients with migraine without aura (MO). In contrast to patients with MO, in prior studies patients with familial hemiplegic migraine (FHM) did not report more migraine-like attacks compared to controls. Whether CGRP triggers migraine in patients with typical (non-hemiplegic) migraine with aura is (MA) unknown. In the present study we examined the migraine inducing effect of CGRP infusion in patients suffering from MA and healthy controls.",

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AU - Hauge, Anne Werner

AU - Olesen, J.

AU - Ashina, Messoud

AU - Olesen, Jes

PY - 2010

Y1 - 2010

N2 - Calcitonin gene-related peptide (CGRP) is a key molecule in migraine pathogenesis. Intravenous CGRP infusion triggers delayed migraine-like attacks in patients with migraine without aura (MO). In contrast to patients with MO, in prior studies patients with familial hemiplegic migraine (FHM) did not report more migraine-like attacks compared to controls. Whether CGRP triggers migraine in patients with typical (non-hemiplegic) migraine with aura is (MA) unknown. In the present study we examined the migraine inducing effect of CGRP infusion in patients suffering from MA and healthy controls.

AB - Calcitonin gene-related peptide (CGRP) is a key molecule in migraine pathogenesis. Intravenous CGRP infusion triggers delayed migraine-like attacks in patients with migraine without aura (MO). In contrast to patients with MO, in prior studies patients with familial hemiplegic migraine (FHM) did not report more migraine-like attacks compared to controls. Whether CGRP triggers migraine in patients with typical (non-hemiplegic) migraine with aura is (MA) unknown. In the present study we examined the migraine inducing effect of CGRP infusion in patients suffering from MA and healthy controls.

U2 - http://dx.doi.org/10.1177/0333102410368444

DO - http://dx.doi.org/10.1177/0333102410368444

M3 - Journal article

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JO - Cephalalgia

JF - Cephalalgia

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