Calpain 3 is important for muscle regeneration: evidence from patients with limb girdle muscular dystrophies

Simon Hauerslev; Marie-Louise Sveen; Morten Duno; Corrado Angelini; John Vissing; Thomas O Krag

doi:10.1186/1471-2474-13-43

Calpain 3 is important for muscle regeneration: evidence from patients with limb girdle muscular dystrophies

Simon Hauerslev, Marie-Louise Sveen, Morten Duno, Corrado Angelini, John Vissing, Thomas O Krag

Research output: Contribution to journal › Journal article › Research › peer-review

55 Citations (Scopus)

Abstract

Limb girdle muscular dystrophy (LGMD) type 2A is caused by mutations in the CAPN3 gene and complete lack of functional calpain 3 leads to the most severe muscle wasting. Calpain 3 is suggested to be involved in maturation of contractile elements after muscle degeneration. The aim of this study was to investigate how mutations in the four functional domains of calpain 3 affect muscle regeneration.

Original language	English
Journal	B M C Musculoskeletal Disorders
Volume	13
Pages (from-to)	43-53
Number of pages	11
ISSN	1471-2474
DOIs	https://doi.org/10.1186/1471-2474-13-43
Publication status	Published - 2012

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title = "Calpain 3 is important for muscle regeneration: evidence from patients with limb girdle muscular dystrophies",

abstract = "Limb girdle muscular dystrophy (LGMD) type 2A is caused by mutations in the CAPN3 gene and complete lack of functional calpain 3 leads to the most severe muscle wasting. Calpain 3 is suggested to be involved in maturation of contractile elements after muscle degeneration. The aim of this study was to investigate how mutations in the four functional domains of calpain 3 affect muscle regeneration.",

author = "Simon Hauerslev and Marie-Louise Sveen and Morten Duno and Corrado Angelini and John Vissing and Krag, {Thomas O}",

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T1 - Calpain 3 is important for muscle regeneration

T2 - evidence from patients with limb girdle muscular dystrophies

AU - Hauerslev, Simon

AU - Sveen, Marie-Louise

AU - Duno, Morten

AU - Angelini, Corrado

AU - Vissing, John

AU - Krag, Thomas O

PY - 2012

Y1 - 2012

N2 - Limb girdle muscular dystrophy (LGMD) type 2A is caused by mutations in the CAPN3 gene and complete lack of functional calpain 3 leads to the most severe muscle wasting. Calpain 3 is suggested to be involved in maturation of contractile elements after muscle degeneration. The aim of this study was to investigate how mutations in the four functional domains of calpain 3 affect muscle regeneration.

AB - Limb girdle muscular dystrophy (LGMD) type 2A is caused by mutations in the CAPN3 gene and complete lack of functional calpain 3 leads to the most severe muscle wasting. Calpain 3 is suggested to be involved in maturation of contractile elements after muscle degeneration. The aim of this study was to investigate how mutations in the four functional domains of calpain 3 affect muscle regeneration.

U2 - 10.1186/1471-2474-13-43

DO - 10.1186/1471-2474-13-43

M3 - Journal article

C2 - 22443334

SN - 1471-2474

VL - 13

SP - 43

EP - 53

JO - B M C Musculoskeletal Disorders

JF - B M C Musculoskeletal Disorders

ER -