Can ambulatory blood pressure measurements substitute assessment of subclinical cardiovascular damage?

Thomas Sehestedt, Jørgen Jeppesen, Tine W Hansen, Susanne Rasmussen, Kristian Wachtell, Hans Ibsen, Christian Torp-Pedersen, Michael H Olsen

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    Abstract

    OBJECTIVE:: We have previously demonstrated that markers of subclinical organ damage (SOD) improve cardiovascular risk prediction in healthy individuals. We wanted to investigate whether this additive effect of SOD was due to inaccurate blood pressure (BP) measurement or whether ambulatory BP (AMBP) added further to risk prediction. METHODS:: In a population cohort of 1385 Danish individuals free of cardiovascular disease and diabetes, we recorded traditional risk factors, AMBP and pulse wave velocity (PWV), urine albumin/creatinine ratio (UACR), left ventricular mass index (LVMI) and carotid atherosclerotic plaques at baseline. A composite cardiovascular endpoint (CEP) consisting of cardiovascular death and nonfatal myocardial infarction and stroke was recorded in national registries. RESULTS:: During a median follow-up of 12.8 years, a total of 119 CEPs occurred. In categorical analysis, presence of SOD as well as masked hypertension increased sensitivity of Systemic Coronary Risk Estimation from 73.9 to 89.1% (P¿
    Original languageEnglish
    JournalJournal of Hypertension
    Volume30
    Issue number3
    Pages (from-to)513-521
    Number of pages9
    ISSN0263-6352
    DOIs
    Publication statusPublished - 2012

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