Cancer associated epigenetic transitions identified by genome-wide histone methylation binding profiles in human colorectal cancer samples and paired normal mucosa

Stefan Enroth; Alvaro Rada-Iglesisas; Robin Andersson; Ola Wallerman; Alkwin Wanders; Lars Påhlman; Jan Komorowski; Claes Wadelius

doi:10.1186/1471-2407-11-450

Cancer associated epigenetic transitions identified by genome-wide histone methylation binding profiles in human colorectal cancer samples and paired normal mucosa

Stefan Enroth, Alvaro Rada-Iglesisas, Robin Andersson, Ola Wallerman, Alkwin Wanders, Lars Påhlman, Jan Komorowski, Claes Wadelius

Computational and RNA Biology

Research output: Contribution to journal › Journal article › Research › peer-review

27 Citations (Scopus)

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Abstract

Despite their well-established functional roles, histone modifications have received less attention than DNA methylation in the cancer field. In order to evaluate their importance in colorectal cancer (CRC), we generated the first genome-wide histone modification profiles in paired normal colon mucosa and tumor samples.

Original language	English
Article number	450
Journal	B M C Cancer
Volume	11
Number of pages	13
ISSN	1471-2407
DOIs	https://doi.org/10.1186/1471-2407-11-450
Publication status	Published - 2011

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10.1186/1471-2407-11-450Licence: CC BY

Cancer...Final published version, 1.03 MBLicence: CC BY

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Cancer associated epigenetic transitions identified by genome-wide histone methylation binding profiles in human colorectal cancer samples and paired normal mucosa. / Enroth, Stefan; Rada-Iglesisas, Alvaro; Andersson, Robin; Wallerman, Ola; Wanders, Alkwin; Påhlman, Lars; Komorowski, Jan; Wadelius, Claes.

In: B M C Cancer, Vol. 11, 450, 2011.

Research output: Contribution to journal › Journal article › Research › peer-review

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title = "Cancer associated epigenetic transitions identified by genome-wide histone methylation binding profiles in human colorectal cancer samples and paired normal mucosa",

abstract = "Despite their well-established functional roles, histone modifications have received less attention than DNA methylation in the cancer field. In order to evaluate their importance in colorectal cancer (CRC), we generated the first genome-wide histone modification profiles in paired normal colon mucosa and tumor samples.",

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AU - Enroth, Stefan

AU - Rada-Iglesisas, Alvaro

AU - Andersson, Robin

AU - Wallerman, Ola

AU - Wanders, Alkwin

AU - Påhlman, Lars

AU - Komorowski, Jan

AU - Wadelius, Claes

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AB - Despite their well-established functional roles, histone modifications have received less attention than DNA methylation in the cancer field. In order to evaluate their importance in colorectal cancer (CRC), we generated the first genome-wide histone modification profiles in paired normal colon mucosa and tumor samples.

U2 - 10.1186/1471-2407-11-450

DO - 10.1186/1471-2407-11-450

M3 - Journal article

C2 - 22011431

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JO - B M C Cancer

JF - B M C Cancer

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