Cellular uptake but low permeation of human calcitonin-derived cell penetrating peptides and Tat(47-57) through well-differentiated epithelial models

Rachel Tréhin; Ulrike Krauss; Annette G Beck-Sickinger; Hans P Merkle; Hanne Mørck Nielsen

Cellular uptake but low permeation of human calcitonin-derived cell penetrating peptides and Tat(47-57) through well-differentiated epithelial models

Rachel Tréhin, Ulrike Krauss, Annette G Beck-Sickinger, Hans P Merkle, Hanne Mørck Nielsen

Biologics

Research output: Contribution to journal › Journal article › Research › peer-review

64 Citations (Scopus)

Abstract

To investigate whether cell penetrating peptides (CPP) derived from human calcitonin (hCT) possess, in addition to cellular uptake, the capacity to deliver their cargo through epithelial barriers.

Original language	English
Journal	Pharmaceutical Research
Volume	21
Issue number	7
Pages (from-to)	1248-56
Number of pages	9
ISSN	0724-8741
Publication status	Published - 2004

Keywords

Animals
Calcitonin
Carrier Proteins
Cell Line
Cell Membrane Permeability
Chromatography, High Pressure Liquid
Epithelial Cells
Fluoresceins
Fluorescent Dyes
Gene Products, tat
Humans
Microscopy, Confocal
Peptide Fragments

Cite this

Cellular uptake but low permeation of human calcitonin-derived cell penetrating peptides and Tat(47-57) through well-differentiated epithelial models. / Tréhin, Rachel; Krauss, Ulrike; Beck-Sickinger, Annette G; Merkle, Hans P; Nielsen, Hanne Mørck.

In: Pharmaceutical Research, Vol. 21, No. 7, 2004, p. 1248-56.

Research output: Contribution to journal › Journal article › Research › peer-review

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abstract = "To investigate whether cell penetrating peptides (CPP) derived from human calcitonin (hCT) possess, in addition to cellular uptake, the capacity to deliver their cargo through epithelial barriers.",

keywords = "Animals, Calcitonin, Carrier Proteins, Cell Line, Cell Membrane Permeability, Chromatography, High Pressure Liquid, Epithelial Cells, Fluoresceins, Fluorescent Dyes, Gene Products, tat, Humans, Microscopy, Confocal, Peptide Fragments",

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T1 - Cellular uptake but low permeation of human calcitonin-derived cell penetrating peptides and Tat(47-57) through well-differentiated epithelial models

AU - Tréhin, Rachel

AU - Krauss, Ulrike

AU - Beck-Sickinger, Annette G

AU - Merkle, Hans P

AU - Nielsen, Hanne Mørck

PY - 2004

Y1 - 2004

N2 - To investigate whether cell penetrating peptides (CPP) derived from human calcitonin (hCT) possess, in addition to cellular uptake, the capacity to deliver their cargo through epithelial barriers.

AB - To investigate whether cell penetrating peptides (CPP) derived from human calcitonin (hCT) possess, in addition to cellular uptake, the capacity to deliver their cargo through epithelial barriers.

KW - Animals

KW - Calcitonin

KW - Carrier Proteins

KW - Cell Line

KW - Cell Membrane Permeability

KW - Chromatography, High Pressure Liquid

KW - Epithelial Cells

KW - Fluoresceins

KW - Fluorescent Dyes

KW - Gene Products, tat

KW - Humans

KW - Microscopy, Confocal

KW - Peptide Fragments

M3 - Journal article

C2 - 15290867

VL - 21

SP - 1248

EP - 1256

JO - Pharmaceutical Research

JF - Pharmaceutical Research

SN - 0724-8741

IS - 7

ER -