Abstract
Objectives: To investigate whether cerebrospinal fluid (CSF) biomarkers of neurodegeneration are altered in narcolepsy in order to evaluate whether the hypocretin deficiency and abnormal sleep-wake pattern in narcolepsy leads to neurodegeneration.
Methods: Twenty-one patients with central hypersomnia (10 type 1 narcolepsy, 5 type 2 narcolepsy, and 6 idiopathic hypersomnia cases), aged 33 years on average and with a disease duration of 2-29 years, and 12 healthy controls underwent CSF analyses of the levels of β-amyloid, total tau protein (T-tau), phosphorylated tau protein (P-tau181), α-synuclein, neurofilament light chain (NF-L), and chitinase 3-like protein-1 (CHI3L1).
Results: Levels of β-amyloid were lower in patients with type 1 narcolepsy (375.4 ± 143.5 pg/mL) and type 2 narcolepsy (455.9 ± 65.0 pg/mL) compared to controls (697.9 ± 167.3 pg/mL, p < .05). Furthermore, in patients with type 1 narcolepsy, levels of T-tau (79.0 ± 27.5 pg/mL) and P-tau181 (19.1 ± 4.3 pg/mL) were lower than in controls (162.2 ± 49.9 pg/mL and 33.8 ± 9.2 pg/mL, p < .05). Levels of α-synuclein, NF-L, and CHI3L1 in CSF from narcolepsy patients were similar to those of healthy individuals.
Conclusion: Six CSF biomarkers of neurodegeneration were decreased or normal in narcolepsy indicating that taupathy, synucleinopathy, and immunopathy are not prevalent in narcolepsy patients with a disease duration of 2-29 years. Lower CSF levels of β-amyloid, T-tau protein, and P-tau181 in narcolepsy may indicate that hypocretin deficiency and an abnormal sleep-wake pattern alter the turnover of these proteins in the central nervous system.
Original language | English |
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Article number | zsw006 |
Journal | Sleep |
Volume | 40 |
Issue number | 1 |
Number of pages | 9 |
ISSN | 0161-8105 |
DOIs | |
Publication status | Published - 1 Jan 2017 |
Keywords
- Adult
- Amyloid beta-Peptides/cerebrospinal fluid
- Biomarkers/cerebrospinal fluid
- Case-Control Studies
- Chitinase-3-Like Protein 1/cerebrospinal fluid
- Female
- Humans
- Hypersomnolence, Idiopathic/cerebrospinal fluid
- Male
- Narcolepsy/cerebrospinal fluid
- Neurodegenerative Diseases/cerebrospinal fluid
- Neurofilament Proteins/cerebrospinal fluid
- Orexins/cerebrospinal fluid
- alpha-Synuclein/cerebrospinal fluid
- tau Proteins/cerebrospinal fluid