TY - JOUR
T1 - Cerebrospinal fluid soluble CD27 is associated with CD8+ T cells, B cells and biomarkers of B cell activity in relapsing-remitting multiple sclerosis
AU - El Mahdaoui, Sahla
AU - Husted, Signe Refstrup
AU - Hansen, Malene Bredahl
AU - Cobanovic, Stefan
AU - Mahler, Mie Reith
AU - Buhelt, Sophie
AU - von Essen, Marina Rode
AU - Sellebjerg, Finn
AU - Christensen, Jeppe Romme
N1 - Publisher Copyright:
© 2023 The Authors
PY - 2023
Y1 - 2023
N2 - Cerebrospinal fluid (CSF) soluble CD27 (sCD27) is a sensitive biomarker of intrathecal inflammation. Although generally considered a biomarker of T cell activation, CSF sCD27 has been shown to correlate with biomarkers of B cell activity in multiple sclerosis. We analyzed CSF from 40 patients with relapsing-remitting multiple sclerosis (RRMS) and nine symptomatic controls using flow cytometry and multiplex electrochemiluminescence immunoassays. CSF sCD27 levels were increased in RRMS and correlated with IgG index, soluble B cell maturation antigen, cell count, B cell frequency and CD8+ T cell frequency. We provide new data indicating that CSF sCD27 is associated with CD8+ T cells and B cells in RRMS.
AB - Cerebrospinal fluid (CSF) soluble CD27 (sCD27) is a sensitive biomarker of intrathecal inflammation. Although generally considered a biomarker of T cell activation, CSF sCD27 has been shown to correlate with biomarkers of B cell activity in multiple sclerosis. We analyzed CSF from 40 patients with relapsing-remitting multiple sclerosis (RRMS) and nine symptomatic controls using flow cytometry and multiplex electrochemiluminescence immunoassays. CSF sCD27 levels were increased in RRMS and correlated with IgG index, soluble B cell maturation antigen, cell count, B cell frequency and CD8+ T cell frequency. We provide new data indicating that CSF sCD27 is associated with CD8+ T cells and B cells in RRMS.
KW - CSF
KW - Intrathecal inflammation
KW - Lymphocytes
KW - RRMS
KW - sBCMA
KW - sCD27
U2 - 10.1016/j.jneuroim.2023.578128
DO - 10.1016/j.jneuroim.2023.578128
M3 - Journal article
C2 - 37321014
AN - SCOPUS:85161643611
VL - 381
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
SN - 0165-5728
M1 - 578128
ER -