Cerebrospinal fluid soluble CD27 is associated with CD8+ T cells, B cells and biomarkers of B cell activity in relapsing-remitting multiple sclerosis

Sahla El Mahdaoui*, Signe Refstrup Husted, Malene Bredahl Hansen, Stefan Cobanovic, Mie Reith Mahler, Sophie Buhelt, Marina Rode von Essen, Finn Sellebjerg, Jeppe Romme Christensen

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Abstract

Cerebrospinal fluid (CSF) soluble CD27 (sCD27) is a sensitive biomarker of intrathecal inflammation. Although generally considered a biomarker of T cell activation, CSF sCD27 has been shown to correlate with biomarkers of B cell activity in multiple sclerosis. We analyzed CSF from 40 patients with relapsing-remitting multiple sclerosis (RRMS) and nine symptomatic controls using flow cytometry and multiplex electrochemiluminescence immunoassays. CSF sCD27 levels were increased in RRMS and correlated with IgG index, soluble B cell maturation antigen, cell count, B cell frequency and CD8+ T cell frequency. We provide new data indicating that CSF sCD27 is associated with CD8+ T cells and B cells in RRMS.

Original languageEnglish
Article number578128
JournalJournal of Neuroimmunology
Volume381
Number of pages6
ISSN0165-5728
DOIs
Publication statusPublished - 2023

Bibliographical note

Publisher Copyright:
© 2023 The Authors

Keywords

  • CSF
  • Intrathecal inflammation
  • Lymphocytes
  • RRMS
  • sBCMA
  • sCD27

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