TY - JOUR
T1 - Changes in tumor vascularity depicted by contrast-enhanced EUS as a predictor of prognosis and treatment efficacy in patients with unresectable pancreatic cancer (PEACE)
T2 - A study protocol
AU - Sãftoiu, Adrian
AU - Bhutani, Manoop S
AU - Itoi, Takao
AU - Arcidiacono, Paolo G
AU - Bories, Erwan
AU - Cazacu, Irina M
AU - Constantin, Alina
AU - Coronel, Emmanuel
AU - Dietrich, Christoph F
AU - Duda, Dan G
AU - Garcia, Julio Iglesias
AU - Hocke, Michael
AU - Ignee, Andre
AU - Jenssen, Christian
AU - Jinga, Mariana
AU - Khor, Christopher
AU - Oppong, Kofi W
AU - Pereira, Stephen
AU - Petrone, Maria Chiara
AU - Santo, Erwin
AU - Seicean, Andrada
AU - Seo, Dong Wan
AU - Siyu, Sun
AU - Vilmann, Peter
AU - Waxman, Irving
AU - Yeaton, Paul
PY - 2019
Y1 - 2019
N2 - Patients with unresectable pancreatic cancer have a poor prognosis. The analysis of prognostic factors before treatment may be helpful in determining the best therapeutic strategies. The aim of the PEACE study is to assess the vascularity of pancreatic malignant tumors using contrast-enhanced harmonic EUS (CEH-EUS) and to clarify the prognostic value of tumor vascularity in patients with locally advanced and metastatic pancreatic cancer. Hereby, we present the protocol of a prospective, nonrandomized, single-arm, multicenter study aiming to assess changes in tumor vascularity using CEH-EUS before and 2 months after treatment initiation in patients with unresectable, locally advanced/metastatic pancreatic cancer and to examine the correlation between vascular changes and treatment response, progression-free survival, and overall survival.
AB - Patients with unresectable pancreatic cancer have a poor prognosis. The analysis of prognostic factors before treatment may be helpful in determining the best therapeutic strategies. The aim of the PEACE study is to assess the vascularity of pancreatic malignant tumors using contrast-enhanced harmonic EUS (CEH-EUS) and to clarify the prognostic value of tumor vascularity in patients with locally advanced and metastatic pancreatic cancer. Hereby, we present the protocol of a prospective, nonrandomized, single-arm, multicenter study aiming to assess changes in tumor vascularity using CEH-EUS before and 2 months after treatment initiation in patients with unresectable, locally advanced/metastatic pancreatic cancer and to examine the correlation between vascular changes and treatment response, progression-free survival, and overall survival.
U2 - 10.4103/eus.eus_16_19
DO - 10.4103/eus.eus_16_19
M3 - Letter
C2 - 31249159
SN - 2303-9027
VL - 8
SP - 235
EP - 240
JO - Endoscopic Ultrasound
JF - Endoscopic Ultrasound
IS - 4
ER -