Characteristics of 86 individuals with mpox diagnosed at Copenhagen University Hospital

Sebastian von Schreeb; Banoo Bakir Exsteen; Mike Zangenberg; Morten Rasmussen; Anders Fromsgaard; Gitte Kronborg; Hvidovre Infectious Diseases Group (HIDG)

Characteristics of 86 individuals with mpox diagnosed at Copenhagen University Hospital

Sebastian von Schreeb, Banoo Bakir Exsteen, Mike Zangenberg, Morten Rasmussen, Anders Fromsgaard, Gitte Kronborg, Hvidovre Infectious Diseases Group (HIDG)

Research output: Contribution to journal › Journal article › Research › peer-review

2 Citations (Scopus)

13 Downloads (Pure)

Abstract

INTRODUCTION: Since the beginning of the mpox (previously called monkeypox) outbreak in 2022, almost half of cases in Denmark have been diagnosed at the Department of Infectious Diseases, Copenhagen University Hospital - Amager and Hvidovre Hospital. This article describes the patient cohort seen at the Department with a view to increasing knowledge of mpox among colleagues who are most likely to identify future cases.

METHODS: A retrospective observational study reporting patient characteristics, coinfections, clinical presentation and diagnostic delay among mpox cases diagnosed at the department between 23 May 2022 and 8 February 2023. Furthermore, a case report of a patient hospitalised with severe rectal pain is presented to highlight anorectal symptoms.

RESULTS: A total of 86 patients were diagnosed with mpox, all were men who have sex with men, with a median age of 39 years. Twenty-six patients (31%) took HIV pre-exposure prophylaxis, and 20 patients (24%) were people living with HIV. All patients (100%) presented with lesions, most frequently on or around the genitals. Twenty-nine patients (35%) had anorectal discomfort or pain. Seven patients (10%) had chlamydia, 19 (26%) gonorrhoea and two (5%) syphilis. In 13 cases (15%), mpox was not suspected at the first medical consultation, mainly because symptoms were attributed to a gonorrhoeal coinfection. Five patients (6%) were hospitalised for a median of three days.

CONCLUSION: As mpox may become endemic in Denmark, clinicians should remain aware of its symptoms and the risk of coinfection with sexually transmitted infections.

FUNDING: None.

TRIAL REGISTRATION: Not relevant.

Original language	English
Article number	A09220544
Journal	Danish Medical Journal
Volume	70
Issue number	5
Number of pages	7
ISSN	2245-1919
Publication status	Published - 2023

Bibliographical note

Articles published in the DMJ are “open access”. This means that the articles are distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits any non-commercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.

Keywords

Adult
Female
Humans
Male
Coinfection
Delayed Diagnosis
HIV Infections
Homosexuality, Male
Hospitals, University
Pain
Sexual and Gender Minorities
Monkeypox/diagnosis

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FulltextFinal published version, 605 KBLicence: CC BY-NC-ND

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Cite this

von Schreeb, S., Exsteen, B. B., Zangenberg, M., Rasmussen, M., Fromsgaard, A., Kronborg, G., & Hvidovre Infectious Diseases Group (HIDG) (2023). Characteristics of 86 individuals with mpox diagnosed at Copenhagen University Hospital. Danish Medical Journal, 70(5), [A09220544]. https://ugeskriftet.dk/dmj/characteristics-86-individuals-mpox-diagnosed-copenhagen-university-hospital

Characteristics of 86 individuals with mpox diagnosed at Copenhagen University Hospital. / von Schreeb, Sebastian; Exsteen, Banoo Bakir; Zangenberg, Mike; Rasmussen, Morten; Fromsgaard, Anders; Kronborg, Gitte; Hvidovre Infectious Diseases Group (HIDG).

In: Danish Medical Journal, Vol. 70, No. 5, A09220544, 2023.

Research output: Contribution to journal › Journal article › Research › peer-review

von Schreeb, S, Exsteen, BB, Zangenberg, M, Rasmussen, M, Fromsgaard, A, Kronborg, G & Hvidovre Infectious Diseases Group (HIDG) 2023, 'Characteristics of 86 individuals with mpox diagnosed at Copenhagen University Hospital', Danish Medical Journal, vol. 70, no. 5, A09220544. <https://ugeskriftet.dk/dmj/characteristics-86-individuals-mpox-diagnosed-copenhagen-university-hospital>

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abstract = "INTRODUCTION: Since the beginning of the mpox (previously called monkeypox) outbreak in 2022, almost half of cases in Denmark have been diagnosed at the Department of Infectious Diseases, Copenhagen University Hospital - Amager and Hvidovre Hospital. This article describes the patient cohort seen at the Department with a view to increasing knowledge of mpox among colleagues who are most likely to identify future cases.METHODS: A retrospective observational study reporting patient characteristics, coinfections, clinical presentation and diagnostic delay among mpox cases diagnosed at the department between 23 May 2022 and 8 February 2023. Furthermore, a case report of a patient hospitalised with severe rectal pain is presented to highlight anorectal symptoms.RESULTS: A total of 86 patients were diagnosed with mpox, all were men who have sex with men, with a median age of 39 years. Twenty-six patients (31%) took HIV pre-exposure prophylaxis, and 20 patients (24%) were people living with HIV. All patients (100%) presented with lesions, most frequently on or around the genitals. Twenty-nine patients (35%) had anorectal discomfort or pain. Seven patients (10%) had chlamydia, 19 (26%) gonorrhoea and two (5%) syphilis. In 13 cases (15%), mpox was not suspected at the first medical consultation, mainly because symptoms were attributed to a gonorrhoeal coinfection. Five patients (6%) were hospitalised for a median of three days.CONCLUSION: As mpox may become endemic in Denmark, clinicians should remain aware of its symptoms and the risk of coinfection with sexually transmitted infections.FUNDING: None.TRIAL REGISTRATION: Not relevant.",

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author = "{von Schreeb}, Sebastian and Exsteen, {Banoo Bakir} and Mike Zangenberg and Morten Rasmussen and Anders Fromsgaard and Gitte Kronborg and {Hvidovre Infectious Diseases Group (HIDG)}",

note = "Articles published in the DMJ are “open access”. This means that the articles are distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits any non-commercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.",

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T1 - Characteristics of 86 individuals with mpox diagnosed at Copenhagen University Hospital

AU - von Schreeb, Sebastian

AU - Exsteen, Banoo Bakir

AU - Zangenberg, Mike

AU - Rasmussen, Morten

AU - Fromsgaard, Anders

AU - Kronborg, Gitte

AU - Hvidovre Infectious Diseases Group (HIDG)

N1 - Articles published in the DMJ are “open access”. This means that the articles are distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits any non-commercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.

PY - 2023

Y1 - 2023

N2 - INTRODUCTION: Since the beginning of the mpox (previously called monkeypox) outbreak in 2022, almost half of cases in Denmark have been diagnosed at the Department of Infectious Diseases, Copenhagen University Hospital - Amager and Hvidovre Hospital. This article describes the patient cohort seen at the Department with a view to increasing knowledge of mpox among colleagues who are most likely to identify future cases.METHODS: A retrospective observational study reporting patient characteristics, coinfections, clinical presentation and diagnostic delay among mpox cases diagnosed at the department between 23 May 2022 and 8 February 2023. Furthermore, a case report of a patient hospitalised with severe rectal pain is presented to highlight anorectal symptoms.RESULTS: A total of 86 patients were diagnosed with mpox, all were men who have sex with men, with a median age of 39 years. Twenty-six patients (31%) took HIV pre-exposure prophylaxis, and 20 patients (24%) were people living with HIV. All patients (100%) presented with lesions, most frequently on or around the genitals. Twenty-nine patients (35%) had anorectal discomfort or pain. Seven patients (10%) had chlamydia, 19 (26%) gonorrhoea and two (5%) syphilis. In 13 cases (15%), mpox was not suspected at the first medical consultation, mainly because symptoms were attributed to a gonorrhoeal coinfection. Five patients (6%) were hospitalised for a median of three days.CONCLUSION: As mpox may become endemic in Denmark, clinicians should remain aware of its symptoms and the risk of coinfection with sexually transmitted infections.FUNDING: None.TRIAL REGISTRATION: Not relevant.

AB - INTRODUCTION: Since the beginning of the mpox (previously called monkeypox) outbreak in 2022, almost half of cases in Denmark have been diagnosed at the Department of Infectious Diseases, Copenhagen University Hospital - Amager and Hvidovre Hospital. This article describes the patient cohort seen at the Department with a view to increasing knowledge of mpox among colleagues who are most likely to identify future cases.METHODS: A retrospective observational study reporting patient characteristics, coinfections, clinical presentation and diagnostic delay among mpox cases diagnosed at the department between 23 May 2022 and 8 February 2023. Furthermore, a case report of a patient hospitalised with severe rectal pain is presented to highlight anorectal symptoms.RESULTS: A total of 86 patients were diagnosed with mpox, all were men who have sex with men, with a median age of 39 years. Twenty-six patients (31%) took HIV pre-exposure prophylaxis, and 20 patients (24%) were people living with HIV. All patients (100%) presented with lesions, most frequently on or around the genitals. Twenty-nine patients (35%) had anorectal discomfort or pain. Seven patients (10%) had chlamydia, 19 (26%) gonorrhoea and two (5%) syphilis. In 13 cases (15%), mpox was not suspected at the first medical consultation, mainly because symptoms were attributed to a gonorrhoeal coinfection. Five patients (6%) were hospitalised for a median of three days.CONCLUSION: As mpox may become endemic in Denmark, clinicians should remain aware of its symptoms and the risk of coinfection with sexually transmitted infections.FUNDING: None.TRIAL REGISTRATION: Not relevant.

KW - Adult

KW - Female

KW - Humans

KW - Male

KW - Coinfection

KW - Delayed Diagnosis

KW - HIV Infections

KW - Homosexuality, Male

KW - Hospitals, University

KW - Pain

KW - Sexual and Gender Minorities

KW - Monkeypox/diagnosis

M3 - Journal article

C2 - 37125825

VL - 70

JO - Danish Medical Journal

JF - Danish Medical Journal

SN - 2245-1919

IS - 5

M1 - A09220544

ER -