TY - JOUR
T1 - Characteristics of patients with COVID-19 pneumonia at Hvidovre Hospital, March-April 2020
AU - Israelsen, Simone Bastrup
AU - Kristiansen, Klaus Tjelle
AU - Hindsberger, Bettina
AU - Ulrik, Charlotte Suppli
AU - Andersen, Ove
AU - Jensen, Magnus
AU - Andersen, Sten
AU - Rasmussen, Christian
AU - Jørgensen, Henrik L
AU - Østergaard, Christian
AU - Lindhardt, Bjarne Ørskov
AU - Kronborg, Gitte
AU - Benfield, Thomas
N1 - Articles published in the DMJ are “open access”. This means that the articles are distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits any non-commercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
PY - 2020/5/15
Y1 - 2020/5/15
N2 - INTRODUCTION: The first case of coronavirus disease 2019 (COVID-19) disease caused by severe acute respiratory syndrome coronavirus-2 occurred in Denmark on 27 February 2020. On 10 March, the first case of COVID-19 pneumonia was admitted to Hvidovre Hospital.METHODS: Retrospective case review of individuals 18 years or older who were admitted consecutively to Hvidovre Hospital from 10 March through 23 April 2020.RESULTS: A total of 175 individuals were admitted with COVID-19 pneumonia. The median age was 71 years, 48.6% were male and 71% had at least one co-morbidity. The most commonly presenting symptoms were dyspnoea, dry cough, and fever. The majority of patients had lymphopenia, elevated liver function tests and C-reactive protein. Nearly two in three presented with multilobar infiltration by chest X-ray. Respiratory failure leading to invasive mechanical ventilation developed in 27 patients (15.4%). By 20 April, 23 of 175 (13.1%) patients remained hospitalised, 43 (24.6%) had died and 109 (62.3%) had been discharged.CONCLUSIONS: The manifestations of COVID-19 at presentation were similar to those seen in other reports. Our population was older, slightly overrepresented by women and had a high level of co-morbidity. COVID-19 admittance was associated with frequent need of intensive care and mechanical ventilation that was associated with a very high mortality.FUNDING: none.TRIAL REGISTRATION: not relevant.
AB - INTRODUCTION: The first case of coronavirus disease 2019 (COVID-19) disease caused by severe acute respiratory syndrome coronavirus-2 occurred in Denmark on 27 February 2020. On 10 March, the first case of COVID-19 pneumonia was admitted to Hvidovre Hospital.METHODS: Retrospective case review of individuals 18 years or older who were admitted consecutively to Hvidovre Hospital from 10 March through 23 April 2020.RESULTS: A total of 175 individuals were admitted with COVID-19 pneumonia. The median age was 71 years, 48.6% were male and 71% had at least one co-morbidity. The most commonly presenting symptoms were dyspnoea, dry cough, and fever. The majority of patients had lymphopenia, elevated liver function tests and C-reactive protein. Nearly two in three presented with multilobar infiltration by chest X-ray. Respiratory failure leading to invasive mechanical ventilation developed in 27 patients (15.4%). By 20 April, 23 of 175 (13.1%) patients remained hospitalised, 43 (24.6%) had died and 109 (62.3%) had been discharged.CONCLUSIONS: The manifestations of COVID-19 at presentation were similar to those seen in other reports. Our population was older, slightly overrepresented by women and had a high level of co-morbidity. COVID-19 admittance was associated with frequent need of intensive care and mechanical ventilation that was associated with a very high mortality.FUNDING: none.TRIAL REGISTRATION: not relevant.
KW - Aged
KW - Aged, 80 and over
KW - Betacoronavirus
KW - Coronavirus Infections/complications
KW - Denmark
KW - Female
KW - Humans
KW - Male
KW - Middle Aged
KW - Pandemics
KW - Pneumonia, Viral/complications
KW - Radiography, Thoracic
KW - Respiration, Artificial
KW - Respiratory Insufficiency/etiology
KW - Retrospective Studies
M3 - Journal article
C2 - 32448405
VL - 67
JO - Danish Medical Journal
JF - Danish Medical Journal
SN - 2245-1919
IS - 6
M1 - A05200313
ER -