Characterization of high pathogenicity avian influenza H5Nx viruses from a wild harbor seal and red foxes in Denmark, 2021 and 2022: Characterization of high pathogenicity avian influenza H5Nx viruses from a wild harbor seal and red foxes in Denmark, 2021 and 2022

Yuan Liang; Charlotte K. Hjulsager; Tim K. Jensen; Anne Sofie V. Hammer; Maibritt T. Ovesen; Lars E. Larsen

doi:10.1111/irv.13208

Characterization of high pathogenicity avian influenza H5Nx viruses from a wild harbor seal and red foxes in Denmark, 2021 and 2022: Characterization of high pathogenicity avian influenza H5Nx viruses from a wild harbor seal and red foxes in Denmark, 2021 and 2022

Yuan Liang^*, Charlotte K. Hjulsager, Tim K. Jensen, Anne Sofie V. Hammer, Maibritt T. Ovesen, Lars E. Larsen

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › Research › peer-review

3 Citations (Scopus)

12 Downloads (Pure)

Abstract

In 2021 and 2022, clade 2.3.4.4b H5Nx high pathogenicity avian influenza viruses were detected in one harbor seal and in one adult and three fox cubs in Denmark. The viruses were closely related to contemporary viruses found in Europe, and some had obtained amino acid substitutions related to mammalian adaptation. Notably, the virus distribution appeared to have been different in the infected fox cubs, as one exclusively tested positive for the presence of HPAIV in the brain and the other two only in the lung. Collectively, these findings stress the need for increased disease surveillance of wild and farmed mammals.

Translated title of the contribution	Characterization of high pathogenicity avian influenza H5Nx viruses from a wild harbor seal and red foxes in Denmark, 2021 and 2022
Original language	English
Article number	e13208
Journal	Influenza and other Respiratory Viruses
Volume	17
Issue number	10
Number of pages	10
ISSN	1750-2640
DOIs	https://doi.org/10.1111/irv.13208
Publication status	Published - 2023

Bibliographical note

Publisher Copyright:
© 2023 The Authors. Influenza and Other Respiratory Viruses published by John Wiley & Sons Ltd.

Keywords

Denmark
high pathogenicity avian influenza
influenza A virus
mammals
wild birds

Access to Document

10.1111/irv.13208Licence: CC BY

FulltextFinal published version, 5.54 MBLicence: CC BY

Cite this

Liang, Y., Hjulsager, C. K., Jensen, T. K., Hammer, A. S. V., Ovesen, M. T., & Larsen, L. E. (2023). Characterization of high pathogenicity avian influenza H5Nx viruses from a wild harbor seal and red foxes in Denmark, 2021 and 2022: Characterization of high pathogenicity avian influenza H5Nx viruses from a wild harbor seal and red foxes in Denmark, 2021 and 2022. Influenza and other Respiratory Viruses, 17(10), [e13208]. https://doi.org/10.1111/irv.13208

Characterization of high pathogenicity avian influenza H5Nx viruses from a wild harbor seal and red foxes in Denmark, 2021 and 2022 : Characterization of high pathogenicity avian influenza H5Nx viruses from a wild harbor seal and red foxes in Denmark, 2021 and 2022. / Liang, Yuan; Hjulsager, Charlotte K.; Jensen, Tim K.; Hammer, Anne Sofie V.; Ovesen, Maibritt T.; Larsen, Lars E.

In: Influenza and other Respiratory Viruses, Vol. 17, No. 10, e13208, 2023.

Research output: Contribution to journal › Journal article › Research › peer-review

Liang, Y, Hjulsager, CK, Jensen, TK , Hammer, ASV , Ovesen, MT & Larsen, LE 2023, 'Characterization of high pathogenicity avian influenza H5Nx viruses from a wild harbor seal and red foxes in Denmark, 2021 and 2022: Characterization of high pathogenicity avian influenza H5Nx viruses from a wild harbor seal and red foxes in Denmark, 2021 and 2022', Influenza and other Respiratory Viruses, vol. 17, no. 10, e13208. https://doi.org/10.1111/irv.13208

Liang Y, Hjulsager CK, Jensen TK , Hammer ASV , Ovesen MT , Larsen LE. Characterization of high pathogenicity avian influenza H5Nx viruses from a wild harbor seal and red foxes in Denmark, 2021 and 2022: Characterization of high pathogenicity avian influenza H5Nx viruses from a wild harbor seal and red foxes in Denmark, 2021 and 2022. Influenza and other Respiratory Viruses. 2023;17(10). e13208. https://doi.org/10.1111/irv.13208

Liang, Yuan ; Hjulsager, Charlotte K. ; Jensen, Tim K. ; Hammer, Anne Sofie V. ; Ovesen, Maibritt T. ; Larsen, Lars E. / Characterization of high pathogenicity avian influenza H5Nx viruses from a wild harbor seal and red foxes in Denmark, 2021 and 2022 : Characterization of high pathogenicity avian influenza H5Nx viruses from a wild harbor seal and red foxes in Denmark, 2021 and 2022. In: Influenza and other Respiratory Viruses. 2023 ; Vol. 17, No. 10.

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title = "Characterization of high pathogenicity avian influenza H5Nx viruses from a wild harbor seal and red foxes in Denmark, 2021 and 2022: Characterization of high pathogenicity avian influenza H5Nx viruses from a wild harbor seal and red foxes in Denmark, 2021 and 2022",

abstract = "In 2021 and 2022, clade 2.3.4.4b H5Nx high pathogenicity avian influenza viruses were detected in one harbor seal and in one adult and three fox cubs in Denmark. The viruses were closely related to contemporary viruses found in Europe, and some had obtained amino acid substitutions related to mammalian adaptation. Notably, the virus distribution appeared to have been different in the infected fox cubs, as one exclusively tested positive for the presence of HPAIV in the brain and the other two only in the lung. Collectively, these findings stress the need for increased disease surveillance of wild and farmed mammals.",

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author = "Yuan Liang and Hjulsager, {Charlotte K.} and Jensen, {Tim K.} and Hammer, {Anne Sofie V.} and Ovesen, {Maibritt T.} and Larsen, {Lars E.}",

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