Chromatin replication and epigenetic cell memory

Kathleen R Stewart-Morgan, Nataliya Petryk, Anja Groth*

*Corresponding author for this work

Research output: Contribution to journalReviewResearchpeer-review

165 Citations (Scopus)
369 Downloads (Pure)

Abstract

Propagation of the chromatin landscape across cell divisions is central to epigenetic cell memory. Mechanistic analysis of the interplay between DNA replication, the cell cycle, and the epigenome has provided insights into replication-coupled chromatin assembly and post-replicative chromatin maintenance. These breakthroughs are critical for defining how proliferation impacts the epigenome during cell identity changes in development and disease. Here we review these findings in the broader context of epigenetic inheritance across mitotic cell division.

Original languageEnglish
JournalNature Cell Biology
Volume22
Pages (from-to)361-371
ISSN1465-7392
DOIs
Publication statusPublished - 2020

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