Chromosomal beta-lactamase is packaged into membrane vesicles and secreted from Pseudomonas aeruginosa.

O Ciofu; T J Beveridge; J Kadurugamuwa; J Walther-Rasmussen; N Høiby

Chromosomal beta-lactamase is packaged into membrane vesicles and secreted from Pseudomonas aeruginosa.

O Ciofu
, T J Beveridge
, J Kadurugamuwa
, J Walther-Rasmussen
, N Høiby

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Membrane vesicles were isolated from one beta-lactam-sensitive and three beta-lactam-resistant Pseudomonas aeruginosa clinical isolates from patients with cystic fibrosis. The presence of the chromosomally encoded beta-lactamase in the membrane vesicles was shown by electron microscopy and enzymatic studies. This is the first report of extracellular secretion of beta-lactamase in P. aeruginosa and it seems that the enzyme is packaged into membrane vesicles.

Original language	English
Journal	Journal of Antimicrobial Chemotherapy
Volume	45
Issue number	1
Pages (from-to)	9-13
Number of pages	4
ISSN	0305-7453
Publication status	Published - 2000

Bibliographical note

Keywords: Cell Membrane; Chromosomes, Bacterial; Cystic Fibrosis; Humans; Lung; Pseudomonas aeruginosa; beta-Lactam Resistance; beta-Lactamases

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title = "Chromosomal beta-lactamase is packaged into membrane vesicles and secreted from Pseudomonas aeruginosa.",

abstract = "Membrane vesicles were isolated from one beta-lactam-sensitive and three beta-lactam-resistant Pseudomonas aeruginosa clinical isolates from patients with cystic fibrosis. The presence of the chromosomally encoded beta-lactamase in the membrane vesicles was shown by electron microscopy and enzymatic studies. This is the first report of extracellular secretion of beta-lactamase in P. aeruginosa and it seems that the enzyme is packaged into membrane vesicles.",

author = "O Ciofu and Beveridge, \{T J\} and J Kadurugamuwa and J Walther-Rasmussen and N H{\o}iby",

note = "Keywords: Cell Membrane; Chromosomes, Bacterial; Cystic Fibrosis; Humans; Lung; Pseudomonas aeruginosa; beta-Lactam Resistance; beta-Lactamases",

year = "2000",

language = "English",

volume = "45",

pages = "9--13",

journal = "Journal of Antimicrobial Chemotherapy",

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T1 - Chromosomal beta-lactamase is packaged into membrane vesicles and secreted from Pseudomonas aeruginosa.

AU - Ciofu, O

AU - Beveridge, T J

AU - Kadurugamuwa, J

AU - Walther-Rasmussen, J

AU - Høiby, N

N1 - Keywords: Cell Membrane; Chromosomes, Bacterial; Cystic Fibrosis; Humans; Lung; Pseudomonas aeruginosa; beta-Lactam Resistance; beta-Lactamases

PY - 2000

Y1 - 2000

N2 - Membrane vesicles were isolated from one beta-lactam-sensitive and three beta-lactam-resistant Pseudomonas aeruginosa clinical isolates from patients with cystic fibrosis. The presence of the chromosomally encoded beta-lactamase in the membrane vesicles was shown by electron microscopy and enzymatic studies. This is the first report of extracellular secretion of beta-lactamase in P. aeruginosa and it seems that the enzyme is packaged into membrane vesicles.

AB - Membrane vesicles were isolated from one beta-lactam-sensitive and three beta-lactam-resistant Pseudomonas aeruginosa clinical isolates from patients with cystic fibrosis. The presence of the chromosomally encoded beta-lactamase in the membrane vesicles was shown by electron microscopy and enzymatic studies. This is the first report of extracellular secretion of beta-lactamase in P. aeruginosa and it seems that the enzyme is packaged into membrane vesicles.

M3 - Journal article

C2 - 10629007

SN - 0305-7453

VL - 45

SP - 9

EP - 13

JO - Journal of Antimicrobial Chemotherapy

JF - Journal of Antimicrobial Chemotherapy

IS - 1

ER -