Abstract
Background: The transition from episodic migraine to chronic migraine, migraine chronification, is usually a gradual process, which involves multiple risk factors. To date, studies of the genetic risk factors for chronic migraine have focused primarily on candidate-gene approaches using healthy individuals as controls. Aims and methods: In this study, we used a large cohort of migraine families and unrelated migraine patients (n > 2200) with supporting genotype and whole-genome sequencing data. We evaluated whether there are any genetic variants, common or rare, with a specific association to chronic migraine compared with episodic migraine. Results: We found no aggregation of chronic migraine in families with a clustering of migraine. No specific rare variants gave rise to migraine chronification, and migraine chronification was not associated with a higher polygenic risk score. Migraine chronification was not associated with allelic associations with an odds ratio above 2.65. Assessment of effect sizes with genome-wide significance below an odds ratio of 2.65 requires a genome-wide association study of at least 7500 chronic migraine patients. Conclusion: Our results suggest that migraine chronification is caused by environmental factors rather than genetic factors.
Original language | English |
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Journal | European Journal of Neurology |
Volume | 28 |
Issue number | 5 |
Pages (from-to) | 1726-1736 |
ISSN | 1351-5101 |
DOIs | |
Publication status | Published - 2021 |
Keywords
- genetics
- genotype
- migraine
- neurology
- sequence analysis