Abstract
The Long QT Syndrome (LQTS) is a genetic disorder, characterized by a long QT interval in the ECG, due to abnormal cardiac repolarization. Apart from the QT interval, various parameters, describing T-wave morphology, have been shown to have diagnostic value, but no single ECG parameter has been sufficient. In this study we present a method for discrimination among normal genotypes and mutations in the KCNQ1 (KvLQT1) and KCNH2 (HERG) genes using parameters describing T-wave morphology in terms of duration, asymmetry, flatness and amplitude. Discriminant analyses based on 3, 4, 5, or 6 parameters all resulted in perfect discrimination in a learning set of 22 subjects with respectively 3, 3, 2, and 3 misclassifications in an evaluation set of 17 subjects. In a combined learning set of all 39 subjects both the 5 and 6 parameter classifiers resulted in a single misclassification.
Original language | English |
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Title of host publication | Computers in Cardiology, 2005 |
Number of pages | 4 |
Volume | 32 |
Publication date | 1 Dec 2005 |
Pages | 511-514 |
Article number | 1588150 |
ISBN (Print) | 0780393376, 9780780393370 |
DOIs | |
Publication status | Published - 1 Dec 2005 |
Event | Computers in Cardiology, 2005 - Lyon, France Duration: 25 Sep 2005 → 28 Sep 2005 |
Conference
Conference | Computers in Cardiology, 2005 |
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Country/Territory | France |
City | Lyon |
Period | 25/09/2005 → 28/09/2005 |