TY - JOUR
T1 - Clinical progression, disease severity, and mortality among adults hospitalized with COVID-19 caused by the Omicron and Delta SARS-CoV-2 variants
T2 - A population-based, matched cohort study
AU - Harboe, Zitta Barrella
AU - Roed, Casper
AU - Holler, Jon Gitz
AU - Khan, Fahim Iqbal
AU - Abdulrahman, Aya Nihad Abdulrahman
AU - Mulverstedt, Stefan Lundby
AU - Lindgaard-Jensen, Betina
AU - Bertelsen, Barbara Bonnesen
AU - Søborg, Christian
AU - Nielsen, Thyge Lynghøj
AU - Hansen, Line Vinum
AU - Madsen, Birgitte Lindegaard
AU - Browatzki, Andrea
AU - Eiberg, Mads
AU - Bernhard, Peter Haahr
AU - Pedersen, Emilie Marie Juelstorp
AU - Egelund, Gertrud Baunbaek
AU - Dungu, Arnold Matovu
AU - Sejdic, Adin
AU - Mathiesen, Inger Hee Mabuza
AU - Jespersen, Naja Z.
AU - Petersen, Pelle Trier
AU - Nielsen, Lars
AU - Jepsen, Micha Phill Grønholm
AU - Pedersen, Thomas Ingemann
AU - Eriksson, Robert
AU - Seitz-Rasmussen, Hans Eric Sebastian
AU - Bestle, Morten
AU - Andersen, Henrik
AU - Skram, Ulrik
AU - Skøtt, Mads Rømer
AU - Altaraihi, Sarah
AU - Sivapalan, Pradeesh
AU - Jensen, Jens Ulrik Stæhr
AU - Bagge, Kristian
AU - Jørgensen, Kristina Melbardis
AU - Knudsen, Maja Johanne Søndergaard
AU - Leineweber, Thomas
AU - Schneider, Uffe Vest
AU - Ahlstrom, Magnus Glindvad
AU - Rytter, Sofie
AU - Le Dous, Nina
AU - Ravn, Pernille
AU - Reiter, Nanna
AU - Podlekareva, Daria
AU - Knudsen, Andreas
AU - Johnsen, Stine
AU - Kristensen, Lars Erik
AU - Leding, Cæcilie
AU - Hertz, Bastian Bryan
AU - Benfield, Thomas
AU - Kirk, Ole
AU - Holler, Jon Gitz
AU - Ostrowski, Sisse Rye
AU - Sigurdsson, Sigurdur Thor
AU - Perner, Anders
AU - Kirkby, Nikolai
AU - Pedersen, Martin Schou
AU - Van Wijhe, Maarten
AU - Simonsen, Lone
AU - Bager, Peter Michael
AU - Krause, Tyra Grove
AU - Voldstedlund, Marianne
AU - Christiansen, Lasse Engbo
AU - Stegger, Marc
AU - Cohen, Arieh
AU - Fonager, Jannik
AU - Fomsgaard, Anders
AU - Legarth, Rebecca
AU - Rasmussen, Morten
AU - Gubbels, Sophie
AU - Wohlfahrt, Jan
AU - Lillebæk, Troels
AU - Johannesen, Caroline Klint
AU - Van Wijhe, Maarten
AU - Fischer, Thea K.
N1 - Publisher Copyright:
© 2023 COVID-19 Omicron Delta study group. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2023
Y1 - 2023
N2 - Background To compare the intrinsic virulence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) omicron variant with the delta variant in hospitalized adults with coronavirus disease 2019 (COVID-19). Methods All adults hospitalized in the Capital Region of Copenhagen with a positive reverse transcription polymerase chain reaction test for SARS-CoV-2 and an available variant determination from 1 September 2021 to 11 February 2022. Data from health registries and patient files were used. Omicron and Delta patients were matched (1:1) by age, sex, comorbidities, and vaccination status. We calculated crude and adjusted hazard ratios (aHRs) for severe hypoxemia and mortality at 30 and 60 days. Results 1,043 patients were included. Patients with Omicron were older, had more comorbidities, were frailer, and more often had three vaccine doses than those with Delta. Fewer patients with Omicron developed severe hypoxemia than those with Delta (aHR, 0.55; 95% confidence interval, 0.38 0.78). Omicron patients exhibited decreased aHR for 30- day mortality compared to Delta (aHR, 0.61; 0.39 0.95). Omicron patients who had received three vaccine doses had lower mortality compared to Delta patients who received three doses (aHR, 0.31;0.16 0.59), but not among those who received two or 0 1 doses (aHR, 0.86; 0.41 1.84 and 0.94; 0.49 1.81 respectively). Similar findings were observed for mortality at 60 days. Similar outcomes were obtained in the analyses of 316 individually matched patients. Conclusions Among adults hospitalized with COVID-19, those with Omicron had less severe hypoxemia and nearly 40% higher 30- and 60-day survival, as compared with those with Delta, mainly driven by a larger proportion of Omicron patients vaccinated with three doses of an mRNA vaccine.
AB - Background To compare the intrinsic virulence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) omicron variant with the delta variant in hospitalized adults with coronavirus disease 2019 (COVID-19). Methods All adults hospitalized in the Capital Region of Copenhagen with a positive reverse transcription polymerase chain reaction test for SARS-CoV-2 and an available variant determination from 1 September 2021 to 11 February 2022. Data from health registries and patient files were used. Omicron and Delta patients were matched (1:1) by age, sex, comorbidities, and vaccination status. We calculated crude and adjusted hazard ratios (aHRs) for severe hypoxemia and mortality at 30 and 60 days. Results 1,043 patients were included. Patients with Omicron were older, had more comorbidities, were frailer, and more often had three vaccine doses than those with Delta. Fewer patients with Omicron developed severe hypoxemia than those with Delta (aHR, 0.55; 95% confidence interval, 0.38 0.78). Omicron patients exhibited decreased aHR for 30- day mortality compared to Delta (aHR, 0.61; 0.39 0.95). Omicron patients who had received three vaccine doses had lower mortality compared to Delta patients who received three doses (aHR, 0.31;0.16 0.59), but not among those who received two or 0 1 doses (aHR, 0.86; 0.41 1.84 and 0.94; 0.49 1.81 respectively). Similar findings were observed for mortality at 60 days. Similar outcomes were obtained in the analyses of 316 individually matched patients. Conclusions Among adults hospitalized with COVID-19, those with Omicron had less severe hypoxemia and nearly 40% higher 30- and 60-day survival, as compared with those with Delta, mainly driven by a larger proportion of Omicron patients vaccinated with three doses of an mRNA vaccine.
UR - http://www.scopus.com/inward/record.url?scp=85158948700&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0282806
DO - 10.1371/journal.pone.0282806
M3 - Journal article
C2 - 37104488
AN - SCOPUS:85158948700
VL - 18
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
IS - 4
M1 - e0282806
ER -