TY - JOUR
T1 - Coating of bone implants with silica, hyperbranched polyethyleneimine, and gentamicin prevents development of osteomyelitis in a porcine model
AU - Jensen, Louise Kruse
AU - Jensen, Henrik Elvang
AU - Blirup-Plum, Sophie Amalie
AU - Bue, Mats
AU - Hanberg, Pelle
AU - Kvich, Lasse
AU - Aalbæk, Bent
AU - López, Yuly
AU - Soto, Sara M.
AU - Douloudi, Marilina
AU - Papageorgiou, Michaela
AU - Nikoli, Eleni
AU - Arkas, Michael
AU - Gutiérrez-del-Río, Ignacio
AU - López-Ibáñez, Sara
AU - Villar, Claudio J.
AU - Lombó, Felipe
AU - Gkomoza, Paraskevi
AU - Kitsou, Ioanna
AU - Tsetsekou, Athina
AU - Vardavoulias, Michalis
N1 - Publisher Copyright:
© 2022 The Authors
PY - 2022
Y1 - 2022
N2 - The use of bone implants and prostheses has contributed to a revolution in modern medicine; however, in the beginning, not much was asked from the implant and prosthetic materials per se. Therefore, the next game-changer in orthopedic research will come from new material designs which for instance can aid in prevention of implant-associated bone infections. Here, we describe the development of a new sol-gel coating technique that can deliver an efficient antimicrobial surface coating on orthopedic implants. Gentamicin was stocked in a novel nanocomposite xerogel made from silica and hyperbranched polyethyleneimine. The xerogel was anchored inside a porous surface made by coating of bone implants with titanium microspheres. Thereby, only the small water-soluble gentamicin molecules diffused in an aqueous environment, i.e., just after surgical insertion and leaving behind a titanium scaffold for osseointegration. The novel xerogel coating prevented development of severe Staphylococcus aureus induced osteomyelitis in a porcine model, which untreated, replicated the pathology seen in stage 3A on the Cierny–Mader classification system for osteomyelitis in adults.
AB - The use of bone implants and prostheses has contributed to a revolution in modern medicine; however, in the beginning, not much was asked from the implant and prosthetic materials per se. Therefore, the next game-changer in orthopedic research will come from new material designs which for instance can aid in prevention of implant-associated bone infections. Here, we describe the development of a new sol-gel coating technique that can deliver an efficient antimicrobial surface coating on orthopedic implants. Gentamicin was stocked in a novel nanocomposite xerogel made from silica and hyperbranched polyethyleneimine. The xerogel was anchored inside a porous surface made by coating of bone implants with titanium microspheres. Thereby, only the small water-soluble gentamicin molecules diffused in an aqueous environment, i.e., just after surgical insertion and leaving behind a titanium scaffold for osseointegration. The novel xerogel coating prevented development of severe Staphylococcus aureus induced osteomyelitis in a porcine model, which untreated, replicated the pathology seen in stage 3A on the Cierny–Mader classification system for osteomyelitis in adults.
KW - Antibacterial coating
KW - Bone implants
KW - Osteomyelitis
KW - Porcine model
U2 - 10.1016/j.mtla.2022.101473
DO - 10.1016/j.mtla.2022.101473
M3 - Journal article
AN - SCOPUS:85132387588
VL - 24
JO - Materialia
JF - Materialia
SN - 2589-1529
M1 - 101473
ER -