Cognitive function is related to fronto-striatal serotonin transporter levels--a brain PET study in young healthy subjects

Karine Madsen; David Frederik Erritzøe; Erik Lykke Mortensen; Anders Gade; Jacob Madsen; William Frans Christiaan Baaré; Gitte M Knudsen; Steen G Hasselbalch

doi:10.1007/s00213-010-1926-4

Cognitive function is related to fronto-striatal serotonin transporter levels--a brain PET study in young healthy subjects

Karine Madsen, David Frederik Erritzøe, Erik Lykke Mortensen, Anders Gade, Jacob Madsen, William Frans Christiaan Baaré, Gitte M Knudsen, Steen G Hasselbalch

Research output: Contribution to journal › Journal article › Research › peer-review

39 Citations (Scopus)

Abstract

Pharmacological manipulation of serotonergic neurotransmission in healthy volunteers impacts on cognitive test performance. Specifically, markers of serotonin function are associated with attention and executive functioning, long-term memory, and general cognitive ability. The serotonin transporter (SERT) protein is a key regulator in the serotonin system. We hypothesized that higher performance on tests sensitive to serotonin would be associated with higher SERT levels in specific fronto-striatal brain regions.

Original language	English
Journal	Psychopharmacology
Volume	213
Issue number	2-3
Pages (from-to)	573-81
Number of pages	9
ISSN	0033-3158
DOIs	https://doi.org/10.1007/s00213-010-1926-4 https://doi.org/10.1007/s00213-010-1926-4
Publication status	Published - 1 Feb 2011

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Madsen, K., Erritzøe, D. F., Mortensen, E. L., Gade, A., Madsen, J., Baaré, W. F. C., Knudsen, G. M., & Hasselbalch, S. G. (2011). Cognitive function is related to fronto-striatal serotonin transporter levels--a brain PET study in young healthy subjects. Psychopharmacology, 213(2-3), 573-81. https://doi.org/10.1007/s00213-010-1926-4, https://doi.org/10.1007/s00213-010-1926-4

Cognitive function is related to fronto-striatal serotonin transporter levels--a brain PET study in young healthy subjects. / Madsen, Karine; Erritzøe, David Frederik; Mortensen, Erik Lykke; Gade, Anders; Madsen, Jacob; Baaré, William Frans Christiaan; Knudsen, Gitte M ; Hasselbalch, Steen G.

In: Psychopharmacology, Vol. 213, No. 2-3, 01.02.2011, p. 573-81.

Research output: Contribution to journal › Journal article › Research › peer-review

Madsen, K, Erritzøe, DF, Mortensen, EL, Gade, A, Madsen, J, Baaré, WFC, Knudsen, GM & Hasselbalch, SG 2011, 'Cognitive function is related to fronto-striatal serotonin transporter levels--a brain PET study in young healthy subjects', Psychopharmacology, vol. 213, no. 2-3, pp. 573-81. https://doi.org/10.1007/s00213-010-1926-4, https://doi.org/10.1007/s00213-010-1926-4

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