TY - JOUR
T1 - Colonic transit time is related to bacterial metabolism and mucosal turnover in the gut
AU - Roager, Henrik Munch
AU - Hansen, Lea Benedicte Skov
AU - Bahl, Martin I
AU - Frandsen, Henrik Lauritz
AU - Carvalho, Vera
AU - Gøbel, Rikke J
AU - Dalgaard, Marlene Danner
AU - Plichta, Damian Rafal
AU - Sparholt, Morten H
AU - Vestergaard, Henrik
AU - Hansen, Torben
AU - Sicheritz-Ponten, Thomas
AU - Nielsen, H Bjørn
AU - Pedersen, Oluf
AU - Lauritzen, Lotte
AU - Kristensen, Mette Bredal
AU - Gupta, Ramneek
AU - Licht, Tine R
N1 - CURIS 2016 NEXS 252
PY - 2016
Y1 - 2016
N2 - Little is known about how colonic transit time relates to human colonic metabolism and its importance for host health, although a firm stool consistency, a proxy for a long colonic transit time, has recently been positively associated with gut microbial richness. Here, we show that colonic transit time in humans, assessed using radio-opaque markers, is associated with overall gut microbial composition, diversity and metabolism. We find that a long colonic transit time associates with high microbial richness and is accompanied by a shift in colonic metabolism from carbohydrate fermentation to protein catabolism as reflected by higher urinary levels of potentially deleterious protein-derived metabolites. Additionally, shorter colonic transit time correlates with metabolites possibly reflecting increased renewal of the colonic mucosa. Together, this suggests that a high gut microbial richness does not per se imply a healthy gut microbial ecosystem and points at colonic transit time as a highly important factor to consider in microbiome and metabolomics studies.
AB - Little is known about how colonic transit time relates to human colonic metabolism and its importance for host health, although a firm stool consistency, a proxy for a long colonic transit time, has recently been positively associated with gut microbial richness. Here, we show that colonic transit time in humans, assessed using radio-opaque markers, is associated with overall gut microbial composition, diversity and metabolism. We find that a long colonic transit time associates with high microbial richness and is accompanied by a shift in colonic metabolism from carbohydrate fermentation to protein catabolism as reflected by higher urinary levels of potentially deleterious protein-derived metabolites. Additionally, shorter colonic transit time correlates with metabolites possibly reflecting increased renewal of the colonic mucosa. Together, this suggests that a high gut microbial richness does not per se imply a healthy gut microbial ecosystem and points at colonic transit time as a highly important factor to consider in microbiome and metabolomics studies.
KW - Journal Article
U2 - 10.1038/nmicrobiol.2016.93
DO - 10.1038/nmicrobiol.2016.93
M3 - Journal article
C2 - 27562254
VL - 1
JO - Nature Microbiology
JF - Nature Microbiology
SN - 2058-5276
IS - 9
M1 - 16093
ER -